2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0813
    Treprostinil diethanolamine 830354-48-8 99.44%
    Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.
    Treprostinil diethanolamine
  • HY-B2119
    Sodium tauroglycocholate 41945-48-6 98%
    Sodium tauroglycocholate is an inhibitor of the biliary acid transporting system of the hepatocyte and also a surfactant used as a chemical permeation enhancer.
    Sodium tauroglycocholate
  • HY-N1163
    Tetrahydroalstonine 6474-90-4 ≥99.0%
    Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury.
    Tetrahydroalstonine
  • HY-N1780
    3,4-Dimethoxyphenol 2033-89-8 99.97%
    3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.
    3,4-Dimethoxyphenol
  • HY-N3078
    p-Hydroxyphenethyl trans-ferulate 84873-15-4 99.68%
    p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast α-glucosidase, IC50=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity.
    p-Hydroxyphenethyl trans-ferulate
  • HY-N3619
    Conophylline 142741-24-0 ≥98.0%
    Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis.
    Conophylline
  • HY-N6969
    Dicentrine 517-66-8 99.94%
    Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates.
    Dicentrine
  • HY-P0024
    Veldoreotide 252845-37-7 98%
    Veldoreotide (DG3173) a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent
    Veldoreotide
  • HY-P1183
    Locustatachykinin I 126985-97-5 98.42%
    Locustatachykinin I is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I is also a substrate for a deamidase.
    Locustatachykinin I
  • HY-P1469
    Bradykinin (1-6) 23815-88-5 99.19%
    Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).
    Bradykinin (1-6)
  • HY-P1490
    Bradykinin (2-9) 16875-11-9
    Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.
    Bradykinin (2-9)
  • HY-P1769
    Angiotensin II (5-8), human 34233-50-6 99.68%
    Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
    Angiotensin II (5-8), human
  • HY-P1905
    [Gln8]-C517 (LH-RH), chicken 47922-48-5 99.97%
    [Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
    [Gln8]-C517 (LH-RH), chicken
  • HY-P3221
    [Leu3]-Oxytocin 4294-11-5 99.93%
    [Leu3]-Oxytocin, an oxytocin analogue, is derived by structural variation in sequence position 3 replaced by leucine (Leu).
    [Leu3]-Oxytocin
  • HY-P4715
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) 213779-11-4 99.08%
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) is a peptide and can be used as a parathyroid hormone (PTH) receptor ligand.
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)
  • HY-100238
    Antihistamine-1 1186430-60-3 99.45%
    Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
    Antihistamine-1
  • HY-100321
    MCHR1 antagonist 2 863115-70-2 98.27%
    MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.
    MCHR1 antagonist 2
  • HY-100812
    2-Hydroxysaclofen 117354-64-0 ≥98.0%
    2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats.
    2-Hydroxysaclofen
  • HY-102032
    Butyryltimolol 106351-79-5 ≥98.0%
    Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol. Butyryltimolol is a β-adrenergic blocker.
    Butyryltimolol
  • HY-103005
    Ramelteon metabolite M-II 896736-21-3 98.24%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
Cat. No. Product Name / Synonyms Application Reactivity