2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1067
    Antazoline hydrochloride 2508-72-7 99.70%
    Antazoline hydrochloride is a 1st generation antihistamine with also anticholinergic properties used to relieve nasal congestion and in eye drops.
    Antazoline hydrochloride
  • HY-109163
    Treprostinil palmitil 1706528-83-7 99.62%
    Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease.
    Treprostinil palmitil
  • HY-125879
    DS08210767 2376334-75-5 99.40%
    DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
    DS08210767
  • HY-19732
    BIBS 39 133085-33-3 99.70%
    BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
    BIBS 39
  • HY-B0216S
    Ethynyl Estradiol-d4 350820-06-3 99.00%
    Ethynyl Estradiol-d4 is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ethynyl Estradiol-d4
  • HY-16756
    Toreforant 952494-46-1 99.82%
    Toreforant is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM.
    Toreforant
  • HY-17428
    Tripelennamine hydrochloride 154-69-8 99.81%
    Tripelennamine hydrochloride, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine hydrochloride lessens the allergic response of the organism caused by histamine. Tripelennamine hydrochloride can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions.
    Tripelennamine hydrochloride
  • HY-A0275
    Amezinium methylsulfate 30578-37-1 99.72%
    Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.
    Amezinium methylsulfate
  • HY-B0971
    Pheniramine maleate 132-20-7 99.94%
    Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects.
    Pheniramine maleate
  • HY-B1273
    Fenipentol 583-03-9 98.28%
    Fenipentol (1-Phenyl-1-pentanol), a synthetic derivative of an ingredient of Curcuma longa that is used as a condiment and dye. Fenipentol is also an orally active choleretic agent that plays an important role in release of secretin, gastrin, and pancreatic secretion of bicarbonate and protein.
    Fenipentol
  • HY-B1510
    Acrivastine 87848-99-5 99.59%
    Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.
    Acrivastine
  • HY-B1830
    Estradiol enanthate 4956-37-0 99.41%
    Estradiol enanthate (E2EN) is a shorter-acting estrogen. Estradiol enanthate is an injectable contraceptive in combination with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, in a pattern similar to menstruation.
    Estradiol enanthate
  • HY-B1866
    Linuron 330-55-2 99.88%
    Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor.
    Linuron
  • HY-B1986
    p,p'-DDE 72-55-9 99.51%
    p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.
    p,p'-DDE
  • HY-N6741
    β-Zearalenol 71030-11-0 99.96%
    β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.
    β-Zearalenol
  • HY-P1390
    d[Cha4]-AVP 500170-27-4 99.27%
    d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.
    d[Cha4]-AVP
  • HY-P1477
    Adrenocorticotropic Hormone (ACTH) (1-39), rat 77465-10-2 98.73%
    Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.
    Adrenocorticotropic Hormone (ACTH) (1-39), rat
  • HY-P1752
    Urocortin II, human 351999-18-3 99.61%
    Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior.
    Urocortin II, human
  • HY-P3061
    [Hyp3]-Bradykinin 37642-65-2 99.01%
    [Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts.
    [Hyp3]-Bradykinin
  • HY-P3862
    [MePhe7]-Neurokinin B 110880-53-0 98.87%
    [MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).
    [MePhe7]-Neurokinin B
Cat. No. Product Name / Synonyms Application Reactivity