2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W014901
    Bisphenol F 620-92-8 99.83%
    Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F
  • HY-W018800
    4(3H)-Quinazolinone 491-36-1
    4(3H)-Quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities.
    4(3H)-Quinazolinone
  • HY-W089845
    Heneicosane 629-94-7 ≥98.0%
    Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs.
    Heneicosane
  • HY-12301
    MK-3697 1224846-01-8 98.83%
    MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.
    MK-3697
  • HY-15853
    MK-7246 1218918-62-7 99.63%
    MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
    MK-7246
  • HY-18006
    NKP608 177707-12-9 99.88%
    NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.
    NKP608
  • HY-B0160
    Lafutidine 118288-08-7 99.95%
    Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease.
    Lafutidine
  • HY-B0548
    Hydroxyzine 68-88-2 99.72%
    Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder.
    Hydroxyzine
  • HY-B1052
    Lofexidine hydrochloride 21498-08-8 99.94%
    Lofexidine (hydrochloride) is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
    Lofexidine hydrochloride
  • HY-N7240
    (Rac)-Juvenile hormone III 24198-95-6
    (Rac)-Juvenile hormone III, a natural compound that can be isolated from farnesoic acid ,is the most widely distributed Juvenile hormone homologue.
    (Rac)-Juvenile hormone III
  • HY-100699
    Clenproperol 38339-11-6 99.44%
    Clenproperol is a β2-adrenergic agonist.
    Clenproperol
  • HY-15477A
    YS-49 monohydrate 3028631-24-2 99.56%
    YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
    YS-49 monohydrate
  • HY-B0170A
    Azatadine dimaleate 3978-86-7 99.85%
    Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.
    Azatadine dimaleate
  • HY-N12634
    Pregnant mare serum gonadotropin 9002-70-4
    Pregnant mare serum gonadotropin (PMSG) is a gonadotropin used to promote follicular development and ovulation in animals. PMSG exerts its regulatory effects by stimulating changes in blood hormones, gonadotropins, and cytoplasmic estradiol receptors in the anterior pituitary and hypothalamus. PMSG is commonly used in livestock to improve reproductive efficiency and can also be utilized for research on estrous cycle regulation.
    Pregnant mare serum gonadotropin
  • HY-W587733
    17α,20β-Dihydroxy-4-pregnen-3-one 1662-06-2
    17α,20β-Dihydroxy-4-pregnen-3-one (17,20β-P) is a maturation-inducing steroid.
    17α,20β-Dihydroxy-4-pregnen-3-one
  • HY-W742821
    (Z)-11-Octadecenal 4273-95-4
    (Z)-11-Octadecenal is a female pheromone with diurnal stability, isolated from the pheromone glands of female rice leaffolder moths.
    (Z)-11-Octadecenal
  • HY-B0202S
    Irbesartan-d4 1216883-23-6 99.46%
    Irbesartan-d4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.
    Irbesartan-d4
  • HY-16751
    Ralinepag 1187856-49-0 99.79%
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
    Ralinepag
  • HY-135270
    ADRA1D receptor antagonist 1 1191908-14-1 98.13%
    ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.
    ADRA1D receptor antagonist 1
  • HY-B0141S3
    Estradiol-d2 53866-33-4 99.44%
    Estradiol-d2 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
    Estradiol-d2
Cat. No. Product Name / Synonyms Application Reactivity