2. Endocrinology

Endocrinology

Endocrinology

Related Products

PDF 21.44 MB

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14875
    Verucerfont 885220-61-1 99.93%
    Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000?nM for CRF1, CRF2, and CRF-BP, respectively.
    Verucerfont
  • HY-A0027
    Fenspiride hydrochloride 5053-08-7 99.11%
    Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases.
    Fenspiride hydrochloride
  • HY-A0295
    (R)-Propranolol hydrochloride 13071-11-9
    (R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
    (R)-Propranolol hydrochloride
  • HY-B0814
    Levocetirizine 130018-77-8 99.41%
    Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.
    Levocetirizine
  • HY-B1392
    Esmolol hydrochloride 81161-17-3 99.92%
    Esmolol hydrochloride is a beta adrenergic receptor blocker.
    Esmolol hydrochloride
  • HY-P3579
    Gastric Inhibitory Peptide, porcine 11063-17-5 99.67%
    Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism.
    Gastric Inhibitory Peptide, porcine
  • HY-101086
    Acetylcholine iodide 2260-50-6 98.59%
    Acetylcholine iodide is a muscarinic receptor modulator. Acetylcholine iodide specifically binds to muscarinic receptors, inhibits sodium absorption, and induces chloride secretion. Acetylcholine iodide changes intestinal ion transport, enhances intestinal secretory function, induces or maintains mammary gland development and lactation. Acetylcholine iodide can be used for intestinal ion transport regulation and mammary gland physiological function research.
    Acetylcholine iodide
  • HY-101336
    RS 17053 hydrochloride 169505-93-5 99.93%
    RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
    RS 17053 hydrochloride
  • HY-101713
    Ilacirnon 1100318-47-5 99.87%
    CCX140 (CCX140-B) is a potent CCR2 antagonist.
    Ilacirnon
  • HY-119384
    Promegestone 34184-77-5 ≥98.0%
    Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research.
    Promegestone
  • HY-15251A
    (Rac)-Reparixin 957407-64-6 99.82%
    (Rac)-Reparixin is the isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
    (Rac)-Reparixin
  • HY-17495A
    Carteolol hydrochloride 51781-21-6 99.96%
    Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma.
    Carteolol hydrochloride
  • HY-B0381A
    Betaxolol hydrochloride 63659-19-8 99.30%
    Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.
    Betaxolol hydrochloride
  • HY-100806R
    Kynurenic acid (Standard) 492-27-3
    Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
    Kynurenic acid (Standard)
  • HY-103454B
    MPP hydrochloride 2863676-89-3 99.28%
    MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.
    MPP hydrochloride
  • HY-14450
    JNJ-31020028 1094873-14-9 98.02%
    JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
    JNJ-31020028
  • HY-17405
    Alarelin Acetate 79561-22-1 ≥98.0%
    Alarelin acetate is a synthetic GnRH agonist.
    Alarelin Acetate
  • HY-A0075
    Decloxizine dihydrochloride 13073-96-6 99.69%
    Decloxizine dihydrochloride(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.
    Decloxizine dihydrochloride
  • HY-158100
    SYD5115 99.69%
    SYD5115 is an orally available TSH-R antagonist.
    SYD5115
  • HY-W039923
    β-D-Galactose pentaacetate 4163-60-4 ≥98.0%
    β-D-Galactose pentaacetate is a negative regulator of insulin with plasma membrane penetrating ability and can be hydrolyzed by intracellular esterases. β-D-Galactose pentaacetate inhibits leucine-induced insulin release in Wistar rat islets, potentially preventing excessive insulin release in pathological conditions.
    β-D-Galactose pentaacetate
Cat. No. Product Name / Synonyms Application Reactivity