2. Cancer
  3. Cancer Metabolism and Metastasis

Cancer Metabolism and Metastasis

Metabolic abnormalities are a major feature of cancer, such as increased substance anabolic pathways and aerobic glycolysis. Cancer metabolism shows flexibility and plasticity, which are crucial for the survival and growth of cancer cells. Cancer metastasis is completed in five steps i.e. invasion, dissemination, circulating tumor cells, colonization, and secondary tumor formation. Recently, metabolic adaptation mechanism of cancer metastasis has been proposed to reveal the extensive relationship between cancer metabolism and cancer metastasis. Metastasizing cancer cells selectively and dynamically adapt their metabolism during the complex multistep cascade.

Many nutrients can promote metabolite plasticity during metastasis. For example, lactic acid and pyruvate are the nutrients that cells can directly absorb from the environment; many cancer cells take up glutamine, which contributes to non-essential amino acid as well as nucleotide synthesis through nitrogen or carbon metabolism. Inhibiting the function of key enzymes in metabolic pathways can in turn inhibit the proliferation of cancer cells. For example, lactate dehydrogenase A or B (LDH-A or -B) knockdown can inhibit breast cancer cell motility in vitro. Oncogenic signaling pathways, such as Myc, phosphoinositide 3-kinase (PI3K)/AKT pathway, MAPK/ERK pathway, LKB1/AMPK pathway and Hippo pathways, mediate metabolic gene expression and increase metabolic enzyme activities.

Cancer Metabolism and Metastasis Related Products (44512):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108017R
    Ferric maltol (Standard) 33725-54-1
    Ferric maltol (Standard) is the analytical standard of Ferric maltol. This product is intended for research and analytical applications. Ferric maltol is an orally active monovalent iron (Fe3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease.
    Ferric maltol (Standard)
  • HY-13756S2
    Tacrolimus-d3
    Tacrolimus-d3 (FK506-d3) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
    Tacrolimus-d<sub>3</sub>
  • HY-169211
    DHFR-IN-21
    DHFR-IN-21 (compund 5p) is a dihydrofolate reductase (DHFR) inhibitor.
    DHFR-IN-21
  • HY-164031
    Cloperidone 4052-13-5
    Cloperidone is an inhibitor for cytochrome P450 2C9 (CYP2C9) with an IC50 of 17.7 μM. Cloperidone exhibits cytotoxicity on HepG2 cells expressing CYP2C9 (60% survival rate at 10 μM).
    Cloperidone
  • HY-126205
    Deacetyleupaserrin 38456-39-2
    Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum.
    Deacetyleupaserrin
  • HY-B0130S1
    Perindopril-d5
    Perindopril-d5 (S-9490-d5) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension.
    Perindopril-d<sub>5</sub>
  • HY-172369
    CARM1/IKZF3 ligand 1
    CARM1/IKZF3 ligand 1 is the inhibitor for CARM1 that can be used as the target protein ligand for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368).
    CARM1/IKZF3 ligand 1
  • HY-N14438
    Furaquinocin A 125108-66-9
    Furaquinocin A can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity.
    Furaquinocin A
  • HY-N4150R
    Quercetagitrin (Standard) 548-75-4
    Quercetagitrin (Standard) is the analytical standard of Quercetagitrin. This product is intended for research and analytical applications. Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes.
    Quercetagitrin (Standard)
  • HY-16273B
    L-778123 dihydrochloride 183499-56-1
    L-778123 dihydrochloride is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM, respectively.
    L-778123 dihydrochloride
  • HY-N3420
    Koaburaside monomethyl ether 41514-64-1
    Koaburaside monomethyl ether is a phenolic glycoside that can be isolated from Averrhoa carambola L..
    Koaburaside monomethyl ether
  • HY-N0858R
    Gomisin G (Standard) 62956-48-3
    Gomisin G (Standard) is the analytical standard of Gomisin G. This product is intended for research and analytical applications. Gomisin G is a lignin from S. chinesis with anti-HIV (EC50 = 0.006 μg/mL), anti-liver cancer and anti-inflammatory activities. Gomisin G has an AKT-cyclin D1 dependent mechanism against triple-negative breast cancer (TNBC) cells through suppressing phosphorylation rather than inducing apoptosis. Gomisin G can inhibit AKT phosphorylation. Gomisin G can cause cell cycle arrest in the G1 phase. Gomisin G can be studied in research for diseases such as HIV, breast and liver cancers.
    Gomisin G (Standard)
  • HY-105129AR
    Pimonidazole (Standard) 70132-50-2
    Pimonidazole (Standard) is the analytical standard of Pimonidazole. This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole (Standard)
  • HY-169634
    JD118 315704-83-7
    JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135).
    JD118
  • HY-W395613
    TY-011 1389439-77-3
    TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research.
    TY-011
  • HY-B1436R
    Nifuroxazide (Standard) 965-52-6
    Nifuroxazide (Standard) is the analytical standard of Nifuroxazide. This product is intended for research and analytical applications. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.
    Nifuroxazide (Standard)
  • HY-158826A
    EZN-2968 sodium
    EZN-2968 sodium is an antisense oligonucleotide that specifically binds and inhibits the expression of HIF-1α mRNA. EZN-2968 sodium, inhibits tumor cell growth.
    EZN-2968 sodium
  • HY-13599S2
    Cladribine-15N 1360874-38-9
    Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
    Cladribine-<sup>15</sup>N
  • HY-N14368
    Flavidulols C 117568-34-0
    Flavidulols C has a suppressive effect on proliferation of mouse lymphocytes.
    Flavidulols C
  • HY-49436
    KTX-582 intermediate-1 845508-29-4 98.61%
    KTX-582 intermediate-1 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].
    KTX-582 intermediate-1