2. Gene
  3. Tcf4 - transcription factor 4 Gene

Tcf4 - transcription factor 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ME2; TFE; E2-2; E2.2; ITF2; SEF2; ITF-2; SEF-2; Tcf-4; ASP-I2; ITF-2b; SEF2-1; MITF-2A; MITF-2B; bHLHb19; 5730422P05Rik

Gene ID: 21413 | Gene type: protein coding

About Tcf4

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tcf4 Products(6)

mRNA Protein Name
NM_001083967.1 NP_001077436.1 transcription factor 4 isoform b
NM_001361126.1 NP_001348055.1 transcription factor 4 isoform b
NM_001361127.1 NP_001348056.1 transcription factor 4 isoform a
NM_001361128.1 NP_001348057.1 transcription factor 4 isoform c
NM_001361129.1 NP_001348058.1 transcription factor 4 isoform c
NM_013685.2 NP_038713.1 transcription factor 4 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
14762206 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8978694 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25620640 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8978694 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
8978694 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8978694 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
25620640 MGI
enables TFIIB-class transcription factor binding IDA
IDA: Inferred from direct assay
8978694 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24192035 MGI
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
20231428 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8999959 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18214987 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
8999959 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within endothelial cell activation IDA
IDA: Inferred from direct assay
20231428 MGI
acts upstream of or within negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
20231428 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
20231428 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
18214987 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8978694 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25620640 MGI
involved in protein-DNA complex assembly IDA
IDA: Inferred from direct assay
8978694 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15351717 MGI
acts upstream of or within regulation of vascular endothelial growth factor signaling pathway IDA
IDA: Inferred from direct assay
20231428 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
8978694 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 4

MITF-2

SL3-3 enhancer factor 2

Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)

class A helix-loop-helix transcription factor ME2

immu

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1360 Chlorquinaldol 98.69% Unkown
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101486 LF3 Antagonist 99.55% Unkown
HY-100760 Toxoflavin Inhibitor 99.88% Unkown
HY-P10392B aStAx-35R TFA 99.18% Unkown
HY-119966 CCT036477 Inhibitor 99.42% Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-124826 BC21 Inhibitor / Unkown
HY-149858 β-catenin-IN-7 Inhibitor / Unkown
HY-157126 Pterostilbene-isothiocyanate Inhibitor / Unkown
HY-172393 TCF4/β-catenin-IN-1 / Unkown
HY-P10392 aStAx-35R / Unkown
HY-RS14307 TCF4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17416 Tcf4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23870 Tcf4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf4 NCBI NCBI:6925