2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P990721
    Inpegsomatropin 2656386-75-1 98%
    Inpegsomatropin is a pegylated long-acting recombinant human growth hormone.
    Inpegsomatropin
  • HY-P991291
    XOMA 129 98%
    XOMA 129 is a human monoclonal antibody targeting INSR. XOMA 129 is an insulin receptor (IR) antagonist that inhibits the drop in blood glucose. XOMA 129 can be used in the study of hypoglycemia .
    XOMA 129
  • HY-P991343
    ALD306 98%
    ALD306 is a human monoclonal antibody (mAb) targeting PCSK9. ALD306 can be used in Hypercholesterolaemia research.
    ALD306
  • HY-P991361
    ABX-10241 98%
    ABX-10241 (ABX-PTH) is a human monoclonal antibody (mAb) targeting Parathyrin. ABX-10241 can be used in Hyperparathyroidism research.
    ABX-10241
  • HY-P991365
    DS-1501 98%
    DS-1501 is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. DS-1501 inhibits osteoclastogenesis. DS-1501 suppresses the decrease of lumbar spine bone mineral density (BMD) in ovariectomized (OVX) rats. DS-1501 can be used in Osteoporosis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    DS-1501
  • HY-P991569
    PF-04840082 98%
    PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research.
    PF-04840082
  • HY-P991677
    Efmirenpase alfa 2770242-54-9 98%
    Efmirenpase alfa is an Fc-ENPP1 fusion protein (human IgG1 Fc domain linked to a modified human ENPP1). Efmirenpase alfa has prolonged half-life and enhanced receptor affinity compared with native human ENPP1. Efmirenpase alfa can be used as an enzyme replacement therapy for ENPP1 deficiency such as arterial calcification and hypophosphatemic rickets research.
    Efmirenpase alfa
  • HY-W008769
    Ethychlozate 27512-72-7 98%
    Ethychlozate is a plant growth regulator on the promotion of flowering in citrus.
    Ethychlozate
  • HY-W022973
    Trinexapac-ethyl 95266-40-3 98%
    Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator.
    Trinexapac-ethyl
  • HY-W073128
    Perfluorotetradecanoic acid 376-06-7 ≥98.0%
    Perfluorotetradecanoic acid (PFTeDA) is a PPARγ inhibitor. Perfluorotetradecanoic acid binds to human PPARγ ligand binding domain with IC50 of 22.8 μM, Kd of 157.8 μM. Perfluorotetradecanoic acid inhibits the function of Leydig cells by inducing oxidative stress and apoptosis. Perfluorotetradecanoic acid stimulates corticosterone biosynthesis but inhibits aldosterone production.
    Perfluorotetradecanoic acid
  • HY-W087008
    7-Hydroxyflavanone 6515-36-2 99.59%
    7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC50 of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula
    7-Hydroxyflavanone
  • HY-W107722
    IN04 838816-57-2 98%
    IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis.
    IN04
  • HY-W108649
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride 34839-14-0
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride is a derivative of 3-chloro-l,2 propanediol (α-chlorohydrin). 3-chloro-l,2 propanediol (a-chlorohydrin) is a male chemosterilant.
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride
  • HY-W192276
    (±)-Desisopropylpropranolol 20862-11-7 98%
    (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    (±)-Desisopropylpropranolol
  • HY-W267205
    3-Acetyl-7-Hydroxycoumarin 10441-27-7 98%
    3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis.
    3-Acetyl-7-Hydroxycoumarin
  • HY-W345393
    Trh-gly 85344-77-0 98%
    Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.
    Trh-gly
  • HY-W585982
    Bisphenol A-β-D-glucuronide 267244-08-6 98%
    Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260).
    Bisphenol A-β-D-glucuronide
  • HY-W587691
    16-Ketoestradiol 566-75-6 98%
    6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone.
    16-Ketoestradiol
  • HY-W601605
    Methosorbinil 102916-95-0 98%
    Methosorbinil is an aldose reductase inhibitor with anti-cataract activity.
    Methosorbinil
  • HY-W653985
    Cortodoxone-d7 98%
    Cortodoxone-d7 (11-Deoxycortisol-d7) is a deuterium labeled Cortodoxone (HY-77839). Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation.
    Cortodoxone-d7
Cat. No. Product Name / Synonyms Application Reactivity