Map2k7 - mitogen-activated protein kinase kinase 7 Gene

Mus musculus

Also known as Mek7; Mkk7; sek2; Jnkk2; MEK 7; JNKK 2; Mapkk7; Prkmk7; MAPKK 7; 5930412N11Rik

Gene ID: 26400 | Gene type: protein coding

About Map2k7

Summary

Enables magnesium ion binding activity; protein kinase activity; and protein Phosphatase binding activity. Involved in several processes, including JNK cascade; cellular response to interleukin-1; and positive regulation of MAPK cascade. Acts upstream of or within regulation of motor neuron apoptotic process and response to wounding. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and sensory organ. Used to study schizophrenia. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Map2k7 Products(6)

mRNA	Protein	Name
NM_001042557.2	NP_001036022.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001164172.1	NP_001157644.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 3
NM_001291777.1	NP_001278706.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 4
NM_001291778.1	NP_001278707.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 5
NM_001291783.1	NP_001278712.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 6
NM_011944.3	NP_036074.2	dual specificity mitogen-activated protein kinase kinase 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase kinase activity	IDA IDA: Inferred from direct assay	9405446	MGI
enables MAP kinase activity	IDA IDA: Inferred from direct assay	9405446	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9405446	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11959861	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	11959862	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	11959862	MGI
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	9405446	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	9405446	MGI
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9405446	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	11959862	MGI
acts upstream of or within regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25100604	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	25100604	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9891090	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9891090	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 7

JNK kinase 2	JNK-activating kinase 2
MAP kinase kinase 7	MAPK/ERK kinase 7
c-Jun N-terminal kinase kinase 2	protein kinase, mitogen activated, kinase 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171178	DK2403		/	Unkown
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown
HY-RS19790	Map2k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26286	Map2k7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k7	NCBI	NCBI:5609

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