2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00290
    R-(+)-Mono-desmethylsibutramine 229639-54-7
    R-(+)-Mono-desmethylsibutramine is the R enantiomer of Mono-desmethylsibutramine.
    R-(+)-Mono-desmethylsibutramine
  • HY-U00303
    Trecadrine 90845-56-0
    Trecadrine is a β3-adrenergic agonist.
    Trecadrine
  • HY-U00358
    Compound 2 872313-42-3
    Compound 2 is an active compound used for the research of metabolic bone diseases.
    Compound 2
  • HY-U00376
    5α-reductase-IN-1 119348-12-8
    5α-reductase-IN-1 is an inhibitor of 5α-reductase, used for the research of patterned alopecia in combination with minoxidil.
    5α-reductase-IN-1
  • HY-101648
    ACAT-IN-1 cis isomer 145961-79-1
    ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM.
    ACAT-IN-1 cis isomer
  • HY-U00020
    AU-224 287399-47-7
    AU-224 is a benzamide derivative used as a promising gastrointestinal prokinetic agent without significant side effects.
    AU-224
  • HY-U00059
    Pyrrole-derivative1 474006-30-9
    Pyrrole-derivative1 is extracted from patent WO/2002/085851A1, example 2, developed for the treatment of diabetic disease.
    Pyrrole-derivative1
  • HY-U00068
    PPARα-MO-1 810677-36-2
    PPARα-MO-1 is a potent PPARα modulator extracted from patent WO/2004/110982A1, formula I.
    PPARα-MO-1
  • HY-U00171
    SQ28603 100845-83-8
    SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
    SQ28603
  • HY-U00193
    Ro18-5362 101387-97-7
    Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.
    Ro18-5362
  • HY-U00200
    Dicirenone 41020-79-5
    Dicirenone (SC26304) inhibits the effects of Aldosterone on urinary K+:Na+ ratios and the binding of [3H]Aldosterone to renal cytoplasmic and nuclear receptors.
    Dicirenone
  • HY-U00216
    NNC45-0781 207277-66-5
    NNC45-0781 is a tissue-selective estrogen partial-agonist.
    NNC45-0781
  • HY-U00244
    Benzquinamide 63-12-7
    Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively.
    Benzquinamide
  • HY-U00245
    L162441 154512-46-6
    L162441 is an Angiotensin type 1 receptor antagonist.
    L162441
  • HY-U00259
    BM152054 213411-84-8
    BM152054 is a potent PPARgamma-activator. BM152054 can promote glucose utilization in peripheral tissues by enhancing insulin action.
    BM152054
  • HY-U00262
    ACT 178882 1007392-69-9
    ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
    ACT 178882
  • HY-U00266
    Cefetrizole 65307-12-2
    Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively.
    Cefetrizole
  • HY-U00270
    CP-319340(free base) 186390-35-2
    CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.
    CP-319340(free base)
  • HY-U00288
    Xanthine oxidase-IN-1 1071970-13-2
    Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
    Xanthine oxidase-IN-1
  • HY-U00329
    Implitapide Racemate 177277-99-5
    Implitapide Racemate is the racemate of Implitapide. Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor.
    Implitapide Racemate
Cat. No. Product Name / Synonyms Application Reactivity