2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N11538
    Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside 69624-79-9
    Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury.
    Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside
  • HY-N11544
    Inflexuside B 1395048-86-8
    Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages.
    Inflexuside B
  • HY-N11548
    Inflexuside A 1395048-85-7
    Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages.
    Inflexuside A
  • HY-N11564
    Aristololactam IIIa 97399-89-8
    Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.
    Aristololactam IIIa
  • HY-N11566
    (+)-Oxypeucedanin methanolate 52939-12-5
    (+)-Oxypeucedanin methanolate (compound 9) is a natural compound with inhibitory effect on prostaglandin E2 production.
    (+)-Oxypeucedanin methanolate
  • HY-N11570
    Phaeocaulisin E 1443040-31-0
    Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC50 of 10.3 μM.
    Phaeocaulisin E
  • HY-N11624
    Axinelline A 1593741-99-1
    Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity.
    Axinelline A
  • HY-N11648
    Ganoderic acid T1
    Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity.
    Ganoderic acid T1
  • HY-N11691
    Thapsigargicin 67526-94-7
    Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets.
    Thapsigargicin
  • HY-N11696
    1-Oxotanshinone IIA 909705-66-4
    1-Oxotanshinone IIA (Compound 6) is extracted from Perovskia artemisioides and has significant anti-inflammatory activity.
    1-Oxotanshinone IIA
  • HY-N11706
    β-Cedrene 546-28-1
    β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM.
    β-Cedrene
  • HY-N11788
    Anti-inflammatory agent 43 2364631-99-0
    Anti-inflammatory agent 43 (compound 3) is a 6-methoxyflavonol glycoside, with anti-inflammatory activity. Anti-inflammatory agent 44 can be isolated from the aerial parts of Tetragonia tetragonoides.
    Anti-inflammatory agent 43
  • HY-N1178R
    Taraxasterol (Standard) 1059-14-9
    Taraxasterol (Standard) is the analytical standard of Taraxasterol. This product is intended for research and analytical applications. Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases.
    Taraxasterol (Standard)
  • HY-N11796
    Anti-inflammatory agent 44 1005416-14-7
    Anti-inflammatory agent 44 (compound 1) is a 6-methoxyflavonol glycoside, with anti-inflammatory activity. Anti-inflammatory agent 44 can be isolated from the aerial parts of Tetragonia tetragonoides.
    Anti-inflammatory agent 44
  • HY-N11845
    Sigmoidin B 87746-47-2
    Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties.
    Sigmoidin B
  • HY-N11887
    Linocinnamarin 554-87-0
    Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca2+ concentration and reactive oxygen species (ROS) .
    Linocinnamarin
  • HY-N11895
    Isorabaichromone 194669-79-9
    Isorabaichromone is a potent antioxidant agent. Isorabaichromone shows a potent antioxidative activity and exhibits DPPH radical and superoxide anion scavenging activities.
    Isorabaichromone
  • HY-N11905
    Kadsurenin A 145701-12-8
    Kadsurenin A is a bioactive Lignan from the genus Piper L.
    Kadsurenin A
  • HY-N11906
    Diayangambin 21453-68-9
    Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) is a cell proliferation inhibitor with an IC50 value of 1.5 μM against human monocytes. Diayangambin also has immunosuppressive and anti-inflammatory effects.
    Diayangambin
  • HY-N11957
    Angeloylbinankadsurin A 77165-80-1
    Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC50=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC50=19.9 μM, 21.93 μM).
    Angeloylbinankadsurin A
Cat. No. Product Name / Synonyms Application Reactivity