2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10835
    Gnetumontanin B 809237-87-4
    Gnetumontanin B is a stilbenoid that can be found in Gnetum montanum f. megalocarpum. Gnetumontanin B inhibits TNF-α production with an IC50 value of 1.49 µM.
    Gnetumontanin B
  • HY-N10844
    Triptohairic acid 220209-71-2
    Triptohairic acid (compound 17) is nature product that could be isolated from the stems of Tripterygium wilfordii. Triptohairic acid has anti-inflammatory activity.
    Triptohairic acid
  • HY-N10865
    Chloranthalactone E 73215-92-6
    Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages.
    Chloranthalactone E
  • HY-N10939
    Gluco-obtusin 960135-79-9
    Gluco-obtusin is an anthraquinone. Gluco-obtusin can be isolated from the seeds of Cassia obtusifolia.
    Gluco-obtusin
  • HY-N10955
    Dichotomine H 1384373-52-7
    Dichotomine H is a P-carboline alkaloid that can be extracted from Stellaria dichotoma L. Dichotomine H has good antiallergic activity.
    Dichotomine H
  • HY-N10985
    Xanthone V1a 103450-96-0
    Xanthone V1a has antioxidant activity against the DPPH radical (IC50: 10.43 µM). Xanthone V1a has cytotoxicity against cancer cells.
    Xanthone V1a
  • HY-N10986
    (±)-Hydnocarpin 298704-61-7
    (±)-Hydnocarpin is a flavonolignan. (±)-Hydnocarpin can inhibit the growth of S. aureus with a MIC50 value of 3.1 μM.
    (±)-Hydnocarpin
  • HY-N1098R
    Velutin (Standard) 25739-41-7
    Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis.
    Velutin (Standard)
  • HY-N11008
    Physagulide J 1496524-09-4
    Physagulide J is a kind of withanolides compound that can be isolated from Physalis angulata L.. Many kinds of active ingredients of Physalis angulata L. shows anti-inflammatory and anti-tumor activity.
    Physagulide J
  • HY-N11011
    Withaphysalin A 57423-72-0
    Withaphysalin A is a withanolide-type compound. Withaphysalin A can be obtained from the anti-inflammatory fraction of P. minima. Withaphysalin A can be used for the research of inflammation.
    Withaphysalin A
  • HY-N11015
    Withaphysalin R 949172-12-7
    Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant.
    Withaphysalin R
  • HY-N11020
    Cabenoside D 88901-40-0
    Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation.
    Cabenoside D
  • HY-N11028
    Isophysalin G 152221-21-1
    Isophysalin G is a steroid that inhibits NO production induced by Lipopolysaccharides (HY-D1056) in macrophages with an IC50 of 64.01 μM.
    Isophysalin G
  • HY-N11085
    Isophysalin A 1363398-67-7
    Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity.
    Isophysalin A
  • HY-N11110
    Inuviscolide 63109-30-8
    Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G2/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities.
    Inuviscolide
  • HY-N11262
    Sudachitin 4281-28-1
    Sudachitin, a polymethoxyflavone that can be isolated from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Sudachitin can activate the p38MAPK pathway and inhibit the ERK1/2 pathway in HaCaT cells.
    Sudachitin
  • HY-N11286
    Tridocosahexaenoylglycerol 124596-98-1
    Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases.
    Tridocosahexaenoylglycerol
  • HY-N11451
    Lacto-N-fucopentaose III 25541-09-7
    Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
    Lacto-N-fucopentaose III
  • HY-N11495
    Hypoletin-7-O-β-D-xylopyranoside 126771-28-6
    Hypoletin-7-O-β-D-xylopyranoside is a natural compound with antioxidant activity.
    Hypoletin-7-O-β-D-xylopyranoside
  • HY-N11496
    17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene 2569209-22-7
    17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity.
    17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene
Cat. No. Product Name / Synonyms Application Reactivity