2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10381
    Zedoalactone B 170384-81-3
    Zedoalactone B is an anti-Babesial agent with an IC50 of 1.6 μg/mL against Babesia gibsoni. Zedoalactone B inhibits NO production with an IC50 of 23.8 μM.
    Zedoalactone B
  • HY-N10397
    Maceneolignan H 1314042-85-7
    Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC50 = 1.4 μM). Maceneolignan H has the potential for the research of allergic diseases.
    Maceneolignan H
  • HY-N10404
    Junceellolide C 121769-82-2
    Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent.
    Junceellolide C
  • HY-N10416
    Neuroinflammatory-IN-1 83988-97-0
    Neuroinflammatory-IN-1 (Compound 5) is an anti-neuroinflammatory agent and displays inhibitory effect on nitric oxide (NO) production with an IC50 value of 65.4 μM.
    Neuroinflammatory-IN-1
  • HY-N10423
    Cubebin 18423-69-3
    Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity.
    Cubebin
  • HY-N10429
    Geissoschizoline 18397-07-4
    Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent.
    Geissoschizoline
  • HY-N10434
    Anti-inflammatory agent 28
    Anti-inflammatory agent 28 (Compound 9) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 28
  • HY-N10435
    Anti-inflammatory agent 29
    Anti-inflammatory agent 29 (Compound 7) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 29
  • HY-N10436
    Anti-inflammatory agent 30 2573174-21-5
    Anti-inflammatory agent 30 (Compound 5) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 30
  • HY-N10438
    Ganodermaones B
    Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression.
    Ganodermaones B
  • HY-N10439
    3β-Acetoxy-hop-22(29)-ene 76582-61-1
    3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC50 of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC50 of 0.23 μmol/ear.
    3β-Acetoxy-hop-22(29)-ene
  • HY-N10440
    3-Oxo-hop-22(29)-ene 25615-11-6
    3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.
    3-Oxo-hop-22(29)-ene
  • HY-N10446
    Maydispenoid B 3024647-69-3
    Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid B
  • HY-N10448
    Sinulatumolin E 2570255-85-3
    Sinulatumolin E (compound 6), a terpenoid, displays significant TNF-α inhibitory activity with an IC50 of 3.6 μM. Sinulatumolin E (compound 6) exhibits anti-inflammatory activity.
    Sinulatumolin E
  • HY-N10453
    Sinulatumolin D
    Sinulatumolin D (compound 4) is an anti-inflammatory agent. Sinulatumolin D has significant TNF-α inhibitory activity with an IC50 value of 5.5 μM.
    Sinulatumolin D
  • HY-N10454
    Sinulatumolin C 2570255-84-2
    Sinulatumolin C (compound 3) is an anti-inflammatory agent. Sinulatumolin C has significant TNF-α inhibitory activity with an IC50 value of 2.6 μM.
    Sinulatumolin C
  • HY-N10458
    Asperbisabolane L
    Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the NF-κB-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells.
    Asperbisabolane L
  • HY-N10511
    GM1a Ganglioside oligosaccharide 67063-78-9
    GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses.
    GM1a Ganglioside oligosaccharide
  • HY-N10520
    Pectic acid 9046-40-6
    Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease.
    Pectic acid
  • HY-N10603
    Praeroside 155969-61-2
    Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation.
    Praeroside
Cat. No. Product Name / Synonyms Application Reactivity