2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10114
    Hyperectumine
    Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.
    Hyperectumine
  • HY-N10156
    1,3,5-Trihydroxy-4-prenylxanthone 53377-61-0
    1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.
    1,3,5-Trihydroxy-4-prenylxanthone
  • HY-N10196
    Cerebroside D 113773-89-0
    Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes.
    Cerebroside D
  • HY-N10214
    (-)-10,11-Dihydroxyfarnesol 37133-76-9
    (-)-10,11-Dihydroxyfarnesol is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. (–)-10,11-Dihydroxyfarnesol significantly inhibits nitric oxide (NO) production.
    (-)-10,11-Dihydroxyfarnesol
  • HY-N10217
    Paneolilludinic acid 847586-20-3
    Paneolilludinic acid is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. Paneolilludinic acid significantly inhibits nitric oxide (NO) production.
    Paneolilludinic acid
  • HY-N10218
    Sterpurol D
    Sterpurol D is a compound of the sterpurane sesquiterpenoid. Sterpurol D significantly inhibits nitric oxide (NO) production.
    Sterpurol D
  • HY-N10227
    Geodin 427-63-4
    Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1).
    Geodin
  • HY-N10231
    Agistatin D 144096-47-9
    Agistatin D is a pyranacetal originally isolated from a Fusarium sp. that inhibits the cholesterol biosynthesis.
    Agistatin D
  • HY-N10238
    Mycestericin G 172519-49-2
    Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity.
    Mycestericin G
  • HY-N10240
    9-Demethyl FR-901235 1029520-85-1
    9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235.
    9-Demethyl FR-901235
  • HY-N10274
    Herpotrichone B 2411834-18-7
    Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.11 μM.
    Herpotrichone B
  • HY-N10275
    Herpotrichone A 2411834-17-6
    Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.41 μM.
    Herpotrichone A
  • HY-N10276
    Morelloflavone 16851-21-1
    Morelloflavone has antioxidative, antiviral, and anti-inflammatory properties.
    Morelloflavone
  • HY-N10294
    Epicoccone B 1067224-41-2
    Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC50 value of 10.8 μM, and has potent α-glucosidase inhibition with IC50 value of 27.3 μM. Anti-HIV activity.
    Epicoccone B
  • HY-N10297
    Curindolizine 1899935-44-4
    Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC50 value of 5.31 μM.
    Curindolizine
  • HY-N10312
    Yadanzigan 76588-87-9
    Yadanzigan (YDZG) is an anti-inflammatory agent and a NLRP3 inhibitor. Yadanzigan specifically inhibits NLRP3 activation via inhibiting NF-κB pathway and Reactive Oxygen Species production. Yadanzigan also moderates LPS (HY-D1056)-induced acute lung injury (ALI) in mice.
    Yadanzigan
  • HY-N10353
    4-Methyl withaferin A 1777780-94-5
    4-Methyl withaferin A is a withaferin A-analogue with anti-tumor activity.
    4-Methyl withaferin A
  • HY-N10359
    Isoandrographolide 4176-96-9
    Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
    Isoandrographolide
  • HY-N10368
    Shinjulactone M 103630-27-9
    Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma.
    Shinjulactone M
  • HY-N10379
    19-epi-Scholaricine 132923-06-9
    19-epi-Scholaricine is an orally active indole alkaloid that downregulates the expression of collagen fibrosis and increases superoxide dismutase (SOD) activities.
    19-epi-Scholaricine
Cat. No. Product Name / Synonyms Application Reactivity