2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14432R
    Pavinetant (Standard) 941690-55-7
    Pavinetant (Standard) is the analytical standard of Pavinetant. This product is intended for research and analytical applications. Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.
    Pavinetant (Standard)
  • HY-14447R
    Bilastine (Standard) 202189-78-4
    Bilastine (Standard) is the analytical standard of Bilastine. This product is intended for research and analytical applications. Bilastine is a histamine H1 receptor antagonist that can be used to treat allergic rhinoconjunctivitis and urticaria.
    Bilastine (Standard)
  • HY-14447S
    Bilastine-d6 1215358-58-9
    Bilastine-d6 is the deuterium labeled Bilastine. Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.
    Bilastine-d6
  • HY-14537R
    Latrepirdine dihydrochloride (Standard) 97657-92-6
    Latrepirdine (dihydrochloride) (Standard) is the analytical standard of Latrepirdine (dihydrochloride). This product is intended for research and analytical applications. Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
    Latrepirdine dihydrochloride (Standard)
  • HY-14552A
    Talnetant hydrochloride 204519-66-4 98%
    Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies.
    Talnetant hydrochloride
  • HY-14734B
    Anamorelin Fumarate 339539-92-3 98%
    Anamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia.
    Anamorelin Fumarate
  • HY-14734R
    Anamorelin (Standard) 249921-19-5
    Anamorelin (Standard) (RC-1291 (Standard)) is the analytical standard of Anamorelin (HY-14734). This product is intended for research and analytical applications. Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia.
    Anamorelin (Standard)
  • HY-14736R
    Azilsartan medoxomil (Standard) 863031-21-4 98%
    Azilsartan medoxomil (Standard) is the analytical standard of Azilsartan medoxomil. This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
    Azilsartan medoxomil (Standard)
  • HY-14773R
    Mirabegron (Standard) 223673-61-8
    Mirabegron (Standard) is the analytical standard of Mirabegron. This product is intended for research and analytical applications. Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
    Mirabegron (Standard)
  • HY-14789R
    (R)-Elagolix (Standard) 834153-87-6
    (R)-Elagolix (Standard) is the analytical standard of (R)-Elagolix. This product is intended for research and analytical applications. Elagolix is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    (R)-Elagolix (Standard)
  • HY-14803R
    Tasimelteon (Standard) 609799-22-6
    Tasimelteon (Standard) is the analytical standard of Tasimelteon. This product is intended for research and analytical applications. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24).
    Tasimelteon (Standard)
  • HY-14803S
    Tasimelteon-d5 1962124-51-1 98%
    Tasimelteon-d5 is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24).
    Tasimelteon-d5
  • HY-14823R
    Sobetirome (Standard) 211110-63-3
    Sobetirome (Standard) is the analytical standard of Sobetirome. This product is intended for research and analytical applications. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.
    Sobetirome (Standard)
  • HY-148301
    6α-Hydroxyestradiol 1229-24-9 98%
    6α-Hydroxyestradiol, a hydroxyestrogen, is an Estradiol (HY-B0141) metabolite.
    6α-Hydroxyestradiol
  • HY-14870R
    Selexipag (Standard) 475086-01-2
    Selexipag (Standard) is the analytical standard of Selexipag. This product is intended for research and analytical applications. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
    Selexipag (Standard)
  • HY-14880A
    Bavisant dihydrochloride 929622-09-3 98%
    Bavisant (JNJ-31001074) dihydrochloride is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
    Bavisant dihydrochloride
  • HY-14882R
    Cenicriviroc (Standard) 497223-25-3
    Cenicriviroc (Standard) is the analytical standard of Cenicriviroc. This product is intended for research and analytical applications. Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
    Cenicriviroc (Standard)
  • HY-14959S
    Ulipristal-d3 98%
    Ulipristal-d3 (CDB-3236-d3) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system.
    Ulipristal-d3
  • HY-15023R
    Cligosiban (Standard) 900510-03-4
    Cligosiban (Standard) is the analytical standard of Cligosiban. This product is intended for research and analytical applications. Cligosiban (PF-3274167) is an orally active, highly selective, and centrally permeable oxytocin receptor antagonist with good pharmacokinetics in rats and can inhibit physiological ejaculation in rodents.
    Cligosiban (Standard)
  • HY-15195R
    Avosentan (Standard) 290815-26-8
    Avosentan (Standard) is the analytical standard of Avosentan (HY-15195). This product is intended for research and analytical applications. Avosentan is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction, and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure.
    Avosentan (Standard)
Cat. No. Product Name / Synonyms Application Reactivity