2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N13290
    10-Chloroestra-1,4-diene-3,17-dione 91413-55-7
    10-Chloroestra-1,4-diene-3,17-dione (10-CIEsra) is a derivative of estrogen receptor.
    10-Chloroestra-1,4-diene-3,17-dione
  • HY-N14632
    Louisianin A 171784-03-5
    Louisianin A is a non-steroidal growth inhibitor of testosterone-responsive SC 115 cells.
    Louisianin A
  • HY-N14633
    Louisianin B 1192169-18-8
    Louisianin B is a non-steroidal growth inhibitor of testosterone-responsive SC 115 cells.
    Louisianin B
  • HY-N14634
    Louisianin C 171784-05-7
    Louisianin C is a non-steroidal growth inhibitor of testosterone-responsive SC 115 cells.
    Louisianin C
  • HY-N15336
    Tschimganin 38970-49-9
    Tschimganin is an ester of terpenoid acids with estrogen activity, which is found in F. tschimganica. Tschimganin can increase the growth of uterus of immature rats.
    Tschimganin
  • HY-N15342
    Tschimganidin 39380-16-0
    Tschimganidin is an ERα agonist with an IC50 of 1.4 μM. Found in plants of the Apiaceae family, Tschimganidin is a terpenoid compound with anti-obesity activity. It can be used for research in the field of endocrine and metabolic disorders.
    Tschimganidin
  • HY-N15362
    5α-Pregnane-3β,17α,20α-triol 570-50-3
    5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. 5α-Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). 5α-Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy.
    5α-Pregnane-3β,17α,20α-triol
  • HY-N15363
    5-Pregnene-3β,17a,20a-triol 85202-13-7
    5-Pregnene-3β,17a,20a-triol is an endogenous steroid compound. 5-Pregnene-3β,17a,20a-triol plays a role in maintaining the body's hormonal balance. 5-Pregnene-3β,17a,20a-triol is promising for research of congenital steroid synthesis enzyme deficiency diseases.
    5-Pregnene-3β,17a,20a-triol
  • HY-N1570R
    Pterosin B (Standard) 34175-96-7
    Pterosin B (Standard) is the analytical standard of Pterosin B (HY-N1570). This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes.
    Pterosin B (Standard)
  • HY-N1919R
    Ajmalicine (Standard) 483-04-5
    Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.
    Ajmalicine (Standard)
  • HY-N2451R
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) 33037-46-6
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
  • HY-N6678R
    Zearalanone (Standard) 5975-78-0
    Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system.
    Zearalanone (Standard)
  • HY-N7104R
    Lactitol (Standard) 585-86-4
    Lactitol (Standard) is the analytical standard of Lactitol. This product is intended for research and analytical applications. Lactitol (D-Lactitol), a nonabsorbable disaccharide, has the potential for constipation research.
    Lactitol (Standard)
  • HY-P10226
    PGD97 2717490-36-1
    PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis.
    PGD97
  • HY-P10336
    Serpinin 1383743-23-4
    Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects.
    Serpinin
  • HY-U00016
    Teoprolol 65184-10-3
    Teoprolol is a β-adrenergic receptor blocker.
    Teoprolol
  • HY-U00018
    (±)-Tazifylline 79712-55-3
    (±)-Tazifylline is a potent, selective and long-acting histamine H1 receptor antagonist.
    (±)-Tazifylline
  • HY-U00019
    Pamatolol 59110-35-9
    Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.
    Pamatolol
  • HY-U00043
    Triamcinolone Benetonide 31002-79-6
    Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
    Triamcinolone Benetonide
  • HY-U00066
    Cicloprolol hydrochloride 63686-79-3
    Cicloprolol is a partial β 1-adrenoceptor agonist .
    Cicloprolol hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity