2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105122
    Zanoterone 107000-34-0 98%
    Zanoterone is an orally active antagonist of the androgen receptor (AR) with a Ki of 2.2 μM. Zanoterone blocks the binding of androgens such as testosterone and dihydrotestosterone (DHT), inhibiting the androgen signaling pathway, thereby reducing androgen-dependent prostate hyperplasia and prostate cancer growth.
    Zanoterone
  • HY-105163
    Finrozole 160146-17-8 98%
    Finrozole (MPV-2213ad) is a nonsteroidal, orally active and competitive aromatase enzyme inhibitor. Finrozole can be used for urinary symptoms research.
    Finrozole
  • HY-105177
    ORG 33628 155768-17-5 98%
    ORG 33628 is a potent and selective progesterone receptor modulator. ORG 33628 shows anti-progestational and anti-glucocorticoid activity. ORG 33628 shows ovulation-inhibitory activity. ORG 33628 has the potential for the research of breast and endometrium.
    ORG 33628
  • HY-105820
    Algestone 595-77-7 98%
    Algestone is a progestin that exhibits hormonal contraceptive effects.
    Algestone
  • HY-106043
    Lutrelin 66866-63-5 98%
    Lutrelin (Wy 40972) is a luteinizing hormone releasing hormone (LHRH) agonist. Lutrelin inhibits the growth of the endometrial expiant in rats.
    Lutrelin
  • HY-106104
    Inocoterone acetate 83646-86-0 98%
    Inocoterone acetate (RU-38882) is a nonsteroidal antiandrogen. Inocoterone acetate binds to the androgen receptor and has antiandrogenic activity in animal models. Inocoterone acetate reduces inflammatory papules and pustules.
    Inocoterone acetate
  • HY-106331
    (Rac)-Sezolamide 123291-07-6 98%
    (Rac)-Sezolamide (MK-927 (free base); (Rac)-MK 417 (free base)) is a carbonic anhydrase inhibitor (CAI) (Ki: 12.0 nM). (Rac)-Sezolamide has a topical intraocular pressure (IOP) lowering effect. (Rac)-Sezolamide can be used in glaucoma research.
    (Rac)-Sezolamide
  • HY-106550
    Enprostil 73121-56-9 98%
    Enprostil (RS 84135) is a prostaglandin E2 derivative. Enprostil can inhibit amogastrin-stimulated gastric acid secretion, as well as reducing the secretion of pepsin. Enprostil can also serve as an antiulcer agent, used for research of duodenal or gastric ulcers.
    Enprostil
  • HY-106562
    Dopexamine 86197-47-9 98%
    Dopexamine is a β2 adrenergic receptor agonist.
    Dopexamine
  • HY-106691
    Pirmagrel 85691-74-3 98%
    Pirmagrel is a thrombin synthetase inhibitor. Pirmagrel has inhibitory effects on thrombin secretion stimulated by lipopolysaccharide (HY-D1056).
    Pirmagrel
  • HY-108056
    PF 219061 547770-05-8 98%
    PF 219061 is an selective agonist for dopamine 3 receptor with an EC50 of 15 nM. PF 219061 exhibits a rapid absorption and a good liver blood clearance, and can be used for research of female sexual dysfunction.
    PF 219061
  • HY-10805R
    Almorexant (Standard) 871224-64-5
    Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
    Almorexant (Standard)
  • HY-10895R
    SB-334867 (Standard) 249889-64-3
    SB-334867 (Standard) is the analytical standard of SB-334867. This product is intended for research and analytical applications. SB-334867 (SB 334867A) is an excellent,selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.
    SB-334867 (Standard)
  • HY-11103R
    Sitaxsentan sodium (Standard) 210421-74-2
    Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan (sodium). This product is intended for research and analytical applications. Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.
    Sitaxsentan sodium (Standard)
  • HY-111291
    ICI 169369 free base 85273-95-6 98%
    ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats.
    ICI 169369 free base
  • HY-111302
    Norgestrienone 848-21-5 98%
    Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema.
    Norgestrienone
  • HY-111309
    LGD-2941 847235-85-2 98%
    LGD-2941 is an orally active, potent and selective androgen receptor modulator. LGD-2941 shows excellent anabolic activity in muscle with reduced effect on the prostate in a rat model of hypogonadism. LGD-2941 also improves bone strength in a rat model of post-menopausal osteoporosis.
    LGD-2941
  • HY-111479
    Amibegron 121524-08-1 98%
    Amibegron is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron has anxiolytic and antidepressant activity.
    Amibegron
  • HY-113488
    8,9-Epoxyeicosatrienoic acid 81246-85-7 98%
    8,9-Epoxyeicosatrienoic acid has an unique protective effect on glomeruli. 8,9-Epoxyeicosatrienoic acid blocks the increase in glomerular albumin permeability caused by circulating permeability factor (FSPF). 8,9-Epoxyeicosatrienoic acid can be used for the research of glomerular dysfunction.
    8,9-Epoxyeicosatrienoic acid
  • HY-114501
    Z3-Dodecenyl E2-butenoate 104086-73-9 98%
    Z3-Dodecenyl E2-butenoate is a female sex pheromone produced by the sweet potato weevil, C. formicarius. It has been used to bait and trap male sweet potato weevils to manage population counts in agriculture fields with reduced use of insecticides.
    Z3-Dodecenyl E2-butenoate
Cat. No. Product Name / Synonyms Application Reactivity