2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W753635
    EC 313 1249398-29-5 98%
    EC 313 is a novel selective progesterone receptor modulator. EC 313 can dose dependently reduce the weight of fibroids. EC 313 can reduce the expression of ER and PR. EC 313 can be used for the study of uterine fibroids.
    EC 313
  • HY-W753897
    Gestodene-d7 98%
    Gestodene-d7 is the deuterium labeled Gestodene (HY-B0110). Gestodene is a progestin-based contraceptive. Gestodene is a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an azide group.
    Gestodene-d7
  • HY-W755511
    Lodoxamide-15N2,d2 2733832-83-0 98%
    Lodoxamide-15N2,d2 (U-42585E (free acid)-15N2,d2) is the deuterium and 15N-labeled Lodoxamide (HY-14270). Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
    Lodoxamide-15N2,d2
  • HY-W758421
    Diquat-d8 dibromide 98%
    Diquat-d8 dibromide is a deuterium labeled Diquat dibromide (HY-122984). Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds.
    Diquat-d8 dibromide
  • HY-W758934
    Stepronin-d5 98%
    Stepronin-d5 (Prostenoglycine-d5; TTPG-d5; Tiase-d5) is the deuterium labeled Stepronin (HY-A0234). Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.
    Stepronin-d5
  • HY-W759219
    Adrenosterone-13C3 98%
    Adrenosterone-13C3 ((+)-Adrenosterone-13C3) is the 13C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
    Adrenosterone-13C3
  • HY-W777002
    Famotidine-13C3 1185241-48-8 98%
    Famotidine-13C3 (MK-208-13C3) is the 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
    Famotidine-13C3
  • HY-W777281
    Fluocinolone acetonide-13C3 1262192-25-5 98%
    Fluocinolone acetonide-13C3 is the 13C-labeled Fluocinolone (Acetonide) (HY-B0415). Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).
    Fluocinolone acetonide-13C3
  • HY-W777284
    Zeranol-d5 (mixture of diastereomers) 1217532-71-2 98%
    Zeranol-d5 (mixture of diastereomers) is the deuterium labeled Zeranol (HY-N6709). Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity.
    Zeranol-d5 (mixture of diastereomers)
  • HY-W777677
    Bisphenol b-D-glucuronide A-d6 1610029-53-2 98%
    Bisphenol b-D-glucuronide A-d6 is the deuterium labeled Bisphenol A-β-D-glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260).
    Bisphenol b-D-glucuronide A-d6
  • HY-W778408
    Tamoxifen-13C6 1346606-38-9 98%
    Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER transgenic mouse.
    Tamoxifen-13C6
  • HY-Y0978S2
    Boc-Glycine-2-13C 145143-02-8 98%
    Boc-Glycine-2-13C is a 13C-labeled Boc-Glycine (HY-Y0978). Boc-Glycine is a Glycine (HY-Y0966) derivative.
    Boc-Glycine-2-13C
  • HY-100441S1
    Treprostinil-13C2,d1 98%
    Treprostinil-13C2,d is the 13C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil-13C2,d1
  • HY-113251S1
    2-Hydroxyestrone-13C6 98%
    2-Hydroxyestrone-13C6 is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic.
    2-Hydroxyestrone-13C6
  • HY-113459S1
    13,14-Dihydro-15-keto Prostaglandin F2α-d4 42932-59-2 98%
    13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy.
    13,14-Dihydro-15-keto Prostaglandin F2α-d4
  • HY-115433S1
    α-Muricholic acid-d4 98%
    α-Muricholic acid-d4 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents.
    α-Muricholic acid-d4
  • HY-116214S1
    Cyprodinil-13C6 1773496-63-1 98%
    Cyprodinil-13C6 (CGA-219417-13C6) is the 13C6 labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
    Cyprodinil-13C6
  • HY-128417S2
    D-Glucose-1,6-13C2 287100-67-8 98%
    D-Glucose-1,6-13C2 is the 13C-labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.
    D-Glucose-1,6-13C2
  • HY-135581S1
    Raloxifene 6-glucuronide-d4 lithium 98%
    Raloxifene 6-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.
    Raloxifene 6-glucuronide-d4 lithium
  • HY-135582S1
    Raloxifene 4'-glucuronide-d4 lithium 98%
    Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.
    Raloxifene 4'-glucuronide-d4 lithium
Cat. No. Product Name / Synonyms Application Reactivity