2. Endocrinology

Endocrinology

Endocrinology

Related Products

PDF 21.44 MB

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120467
    Bima SA 1175838-84-2
    Bima SA (Bimatoprost serinol amide) is a Prostaglandin analog and has the potential for the research of glaucoma.
    Bima SA
  • HY-120585
    L-365209 122211-30-7
    L-365209 is a oxytocin antagonist and can be isolated from Streptomyces .
    L-365209
  • HY-120982
    (+)-15-epi Cloprostenol 54276-22-1
    Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However, the specific activity of this isomer has not been well studied.
    (+)-15-epi Cloprostenol
  • HY-121367
    Lythrine 5286-10-2
    Lythrine is an alkaloid originally isolated from H. salicifolia that inhibits prostaglandin synthetase (IC50=469 μM).
    Lythrine
  • HY-121779
    o,p'-DDE 3424-82-6
    o,p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. It induces concentration-dependent estradiol secretion in co-cultures of granulosa and theca cells isolated from porcine follicles. In ovo exposure to o,p'-DDE increases follicular degeneration and reduces testis size in Japanese medaka (O. latipes).
    o,p'-DDE
  • HY-121973
    Juvocimene II 75539-63-8
    Juvocimene II is a compound with extremely high juvenile hormone (JH) activity, exhibiting potent insect hormone mimetic capabilities.
    Juvocimene II
  • HY-12199A
    Pitolisant oxalate 362665-57-4
    Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
    Pitolisant oxalate
  • HY-12199S
    Pitolisant-d10
    Pitolisant-d10 (Tiprolisant-d10) is deuterium labeled Pitolisant. Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
    Pitolisant-d10
  • HY-122213
    RU-25055 67983-56-6
    RU-25055 is a potent antiglucocorticoid. RU-25055 inhibits early antigen production of the EpsteinBarr virus (EBV) by dexamethasone.
    RU-25055
  • HY-122399
    Luprostiol 67110-79-6
    Luprostiol is a prostaglandin analog. Luprostiol can be used to stimulate endocrine changes in animals.
    Luprostiol
  • HY-123247
    LY113174 112959-07-6
    LY113174 is an orally active aromatase inhibitor (IC50 = 24 nM). LY113174 blocks testosterone induced increase in uterine weight in rat, and inhibits ovarian estrogen biosynthesis.
    LY113174
  • HY-123311
    CP59430 86329-06-8
    CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α1-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α1-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization.
    CP59430
  • HY-123323
    MK-0434 134067-56-4
    MK-0434 is an orally active steroid 5α-reductase inhibitor. MK-0434 specifically inhibits steroid 5α-reductase, thereby reducing the level of dihydrotestosterone (DHT) in the body. MK-0434 can be used in the study of benign prostatic hyperplasia.
    MK-0434
  • HY-123698
    Mebolazine 3625-07-8
    Mebolazine binds to the androgen receptor and produce androgenic and anabolic activity.
    Mebolazine
  • HY-124114
    4-Hydroxytoremifene 110503-62-3
    4-Hydroxytoremifene (4-OH-TOR) is an estrogen receptor antagonist that blocks the uterus's ability to absorb estradiol.
    4-Hydroxytoremifene
  • HY-124175
    16-Phenoxy prostaglandin F2α ethyl amide 951319-59-8
    16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable PGF2α analogue containing a acetamide structure.
    16-Phenoxy prostaglandin F2α ethyl amide
  • HY-124200
    AL 8810 isopropyl ester 208114-93-6
    AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).
    AL 8810 isopropyl ester
  • HY-124209
    9-keto Fluprostenol 156406-33-6
    9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist.
    9-keto Fluprostenol
  • HY-125314
    AG-041R 159883-95-1
    AG-041R is a potent and selective CCK2 Receptor/Gastrin antagonist. AG-041R inhibits gastrin-evoked secretion of pancreastatin with an IC50 of 2.2 nM. AG-041R inhibits cell growth of Mastomys ECL carcinoid tumor cells.
    AG-041R
  • HY-12532R
    Astemizole (Standard) 68844-77-9
    Astemizole (Standard) is the analytical standard of Astemizole. This product is intended for research and analytical applications. Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects.
    Astemizole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity