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Isoforms Recommended:	Phospholipase A

Results for "

spla2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) COX (2) Endogenous Metabolite (1) Glucosidase (1) Phospholipase (18) Prostaglandin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (13) Metabolic Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-11059

sPLA2 inhibitor 1	Phospholipase	Inflammation/Immunology
sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 29 nM for human nonpancreatic secretory PLA₂ isoform IIa (hnpsPLA₂-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity .

HY-107393

LY-311727	Phospholipase	Inflammation/Immunology
LY-311727 is a potent secretory non-pancreatic phospholipase A₂ (sPLA₂) inhibitor (IC₅₀ <1 μM for group IIA sPLA₂). sPLA₂ is an important proinflammatory enzyme ^[2].

HY-13402

Varespladib 5 Publications Verification LY315920	Phospholipase	Inflammation/Immunology
Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on *sPLA2* activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-13402A

Varespladib sodium 5 Publications Verification LY315920 sodium	Phospholipase	Inflammation/Immunology
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on *sPLA2* activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-120441

CAY10590 GK115	Phospholipase Prostaglandin Receptor	Inflammation/Immunology
CAY10590 (GK115) is an inhibitor of secreted phospholipase A₂ (sPLA₂) and can be used for the research of chronic inflammatory kidney diseases .

HY-169254

sPLA2 inhibitor 2	Phospholipase Virus Protease	Metabolic Disease
sPLA2 inhibitor 2 (compound 6a) is a *sPLA2* inhibitor, with IC₅₀ of 0.0475 μM. sPLA2 inhibitor 2 can be used in diabetes research .

HY-169255

sPLA2 inhibitor 3	Phospholipase Glucosidase	Metabolic Disease
sPLA2 inhibitor 3 (Compound 6c) is a potent α-glucosidase inhibitor (IC₅₀ = 0.0953 µM). sPLA2 inhibitor 3 can be used for the research of diabetes .

HY-112605

sPLA2-X Inhibitor 31	Phospholipase	Cardiovascular Disease
sPLA2-X Inhibitor 31 is a selective secreted phospholipase A₂ type X (sPLA₂-X) inhibitor with IC₅₀s of 26 nM, 310 nM, and 2230 nM for *sPLA₂-X, sPLA₂-IIa, and sPLA₂-V*, respectively .

HY-125157

Me-Indoxam	Phospholipase	Inflammation/Immunology
Me-Indoxam is a potent and cell-impermeable secreted phospholipase A₂ (sPLA₂) inhibitor .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-W127380

Arachidonoyl thio-PC	Biochemical Assay Reagents	Others
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-N0134

Tanshinone I 3 Publications Verification Tanshinone A	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I is an inhibitor of type IIA human recombinant *sPLA₂* (IC₅₀=11 μM) and rabbit recombinant *cPLA₂* (IC₅₀=82 μM).

HY-133233

Thioetheramide-PC 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine	Endogenous Metabolite	Metabolic Disease
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC₅₀ value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

HY-17485

Alminoprofen EB-382	Phospholipase COX	Inflammation/Immunology
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and *COX-2* .

HY-125744

Palmitoyl thio-PC	Biochemical Assay Reagents	Others
Palmitoyl thio-PC is a chromogenic substrate specific for PLA2 with a palmitoyl thioester at the sn-2 position. Palmitoyl thio-PC could be used to measure bee-venom sPLA2 activity in a phospholipid:Triton X-100 mixed micelle system .

HY-N0134R

Tanshinone I (Standard)	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC₅₀=11 μM) and rabbit recombinant cPLA2 (IC₅₀=82 μM).

HY-158792

GK241	Others	Others
GK241 (compound 31a-c) is a 2-oxoamide-based compound that has inhibitory activity against human and mouse group IIA secretory phospholipase A2 (GIIA sPLA2) (IC₅₀ of 143 nM and 68 nM, respectively), and its inhibitory mechanism was studied by molecular dynamics simulation.

HY-17485R

Alminoprofen (Standard)	Phospholipase COX	Inflammation/Immunology
Alminoprofen (Standard) is the analytical standard of Alminoprofen. This product is intended for research and analytical applications. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and *COX-2* .

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-134082A

(Z)-Oleyloxyethyl phosphorylcholine	Phospholipase	Inflammation/Immunology
(Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis ^[2].

HY-145384

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of *ERK1/2* and p-38. *Secreted phospholipases A2 (sPLA2s)* are a family of disulfide-rich, Ca ²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .

Cat. No.	Product Name	Type

HY-W127380

Arachidonoyl thio-PC	Enzyme Substrates
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Arachidonoyl thio-PC

Enzyme Substrates

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Cat. No.	Product Name	Target	Research Area

HY-P10053

sPLA2-IIA Inhibitor	Peptides	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

Tris(2,4-di-tert-butylphenyl)phosphate	Natural Products Verbenaceae Source classification Plants Inflammation/Immunology Disease Research Fields Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

Tanshinone I 3 Publications Verification Tanshinone A	Structural Classification Classification of Application Fields Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants Disease Research Fields Cancer	Phospholipase
Tanshinone I is an inhibitor of type IIA human recombinant *sPLA₂* (IC₅₀=11 μM) and rabbit recombinant *cPLA₂* (IC₅₀=82 μM).

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Natural Products Verbenaceae Source classification Plants Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

Tanshinone I (Standard)	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	Phospholipase
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC₅₀=11 μM) and rabbit recombinant cPLA2 (IC₅₀=82 μM).

Ochnaflavone	Source classification Ochna atropurpurea DC. Plants	Phospholipase
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

Species:	Human (2) Mouse (3)
Tag:	His (4) SUMO (1) Fc (1)
Source:	HEK293 (3) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75977

	PLA2G2A Protein, Human (HEK293, His) Phospholipase A2, membrane associated; EF; GIIC spla2	Human	HEK293
	The PLA2G2A protein is a secreted calcium-dependent phospholipase A2 that selectively targets extracellular phospholipids and contributes to host antimicrobial defense, inflammation, and tissue regeneration. It has phospholipase A2 activity, which preferentially hydrolyzes fatty acyl groups, phosphatidylethanolamine and phosphatidylglycerol. PLA2G2A Protein, Human (HEK293, His) is the recombinant human-derived PLA2G2A protein, expressed by HEK293 , with C-His labeled tag.

HY-P74628

	PLA2G2A Protein, Mouse (P.pastoris, His) 1 Publications Verification Phospholipase A2, membrane associated; EF; GIIC spla2	Mouse	P. pastoris
	PLA2G2A Protein, a phospholipase A2 enzyme, efficiently hydrolyzes phosphatidylethanolamines and phosphatidylglycerols, contributing to lipid membrane remodeling and generating lipid mediators crucial for pathogen clearance.PLA2G2A Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PLA2G2A protein, expressed by P.pastoris , with C-His labeled tag.

HY-P76549

	PLA2G2D Protein, Mouse (HEK293, Fc) Group IID secretory phospholipase A2; GIID spla2; PLA2IID; splash	Mouse	HEK293
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions.It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol.PLA2G2D Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PLA2G2D protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71653

	PLA2G2D Protein, Human (His-SUMO) 2IID; EC 3.1.1.4; GIID spla2; Group IID secretory phospholipase A2; Phospholipase A2 group IID ; Pla2g2d; PLA2IID; stroma-associated homolog	Human	E. coli
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions.It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol.PLA2G2D Protein, Human (His-SUMO) is the recombinant human-derived PLA2G2D protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

HY-P77138

	PLA2G2E Protein, Mouse (HEK293, His) Group IIE secretory phospholipase A2; GIIE spla2	Mouse	HEK293
	The PLA2G2E protein is a secreted calcium-dependent phospholipase A2 that targets extracellular phospholipids. It hydrolyzes the fatty acyl group at the sn-2 position, releasing unsaturated fatty acids, especially lysophosphatidylethanolamine. PLA2G2E Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLA2G2E protein, expressed by HEK293 , with C-His labeled tag.

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HY-P82171

	Secretory Phospholipase A2 Antibody (YA1916) MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; spla2	WB	Human, Mouse, Rat
	Secretory Phospholipase A2 Antibody (YA1916) is a biotin-conjugated non-conjugated IgG antibody, targeting Secretory Phospholipase A2, with a predicted molecular weight of 16 kDa (observed band size: 16 kDa). Secretory Phospholipase A2 Antibody (YA1916) can be used for WB experiment in human, mouse, rat background.

HY-P83173

	PLA2G2A Antibody (YA2918) MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; spla2	WB	Human, Mouse, Rat
	PLA2G2A Antibody (YA2918) is a biotin-conjugated non-conjugated IgG antibody, targeting PLA2G2A, with a predicted molecular weight of 16 kDa (observed band size: 16 kDa). PLA2G2A Antibody (YA2918) can be used for WB experiment in human, mouse, rat background.