2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1266R
    Physostigmine (salicylate) (Standard)
    		Inhibitor
    Physostigmine (salicylate) (Standard) is the analytical standard of Physostigmine (salicylate). This product is intended for research and analytical applications. Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.
    Physostigmine (salicylate) (Standard)
  • HY-W165085
    1,10-Bis(pyridinium)decane
    		Inhibitor 99.66%
    1,10-Bis(pyridinium)decane is an acetylcholinesterase (AchE) inhibitor, with an IC50 of 25.8 nM.
    1,10-Bis(pyridinium)decane
  • HY-105790A
    Piperilate hydrochloride
    		Inhibitor
    Piperilate (Pipethanate) hydrochloride is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate hydrochloride also causes hypotension and rescues mice poisoned by the organophosphates.
    Piperilate hydrochloride
  • HY-B1093R
    Fenchlorphos (Standard)
    		Inhibitor
    Fenchlorphos (Standard) is the analytical standard of Fenchlorphos. This product is intended for research and analytical applications. Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.
    Fenchlorphos (Standard)
  • HY-W654335
    Rivastigmine-d4 tartrate
    		Inhibitor
    Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    Rivastigmine-d<sub>4</sub> tartrate
  • HY-119577R
    Ubretid (Standard)
    Ubretid (Standard) is the analytical standard of Ubretid. This product is intended for research and analytical applications. Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder.
    Ubretid (Standard)
  • HY-B2244R
    Tacrine (hydrochloride) (hydrate) (Standard)
    		Inhibitor
    Tacrine (hydrochloride) (hydrate) (Standard) is the analytical standard of Tacrine (hydrochloride) (hydrate). This product is intended for research and analytical applications. Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
    Tacrine (hydrochloride) (hydrate) (Standard)
  • HY-U00085
    Itameline
    		Agonist
    Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat.
    Itameline
  • HY-B0732AS
    Itopride-d6
    		Antagonist
    Itopride-d6 (HSR803-d6 (free base)) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
    Itopride-d<sub>6</sub>
  • HY-B0815R
    Chlorpyrifos (Standard)
    		Inhibitor
    Chlorpyrifos (Standard) is the analytical standard of Chlorpyrifos. This product is intended for research and analytical applications. Chlorpyrifos is a neurotoxic insecticide that belongs to the class of thionite esters. Chlorpyrifos is also a AChE inhibitor that affects neurological function in insects, humans and other animals. Chlorpyrifos interferes with cell replication and differentiation, ultimately altering synaptic transmission in neurons.
    Chlorpyrifos (Standard)
  • HY-107922R
    Ethopropazine (hydrochloride) (Standard)
    		Inhibitor
    Ethopropazine (hydrochloride) (Standard) is the analytical standard of Ethopropazine (hydrochloride). This product is intended for research and analytical applications. Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease.
    Ethopropazine (hydrochloride) (Standard)
  • HY-B1885R
    Fenitrothion (Standard)
    		Inhibitor
    Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies.
    Fenitrothion (Standard)
  • HY-U00028
    T 82
    		Inhibitor
    T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease.
    T 82
  • HY-W042583
    Deoxynojirimycin tetrabenzyl ether
    		Inhibitor
    Deoxynojirimycin tetrabenzyl ether (compound 2) is an inhibitor of hBuChE with IC50 value of 2.0 μM.
    Deoxynojirimycin tetrabenzyl ether
  • HY-W415004
    ACHE-IN-38
    		Inhibitor
    ACHE-IN-38 (Compound mol-8) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission.
    ACHE-IN-38
  • HY-N15414
    Demethoxykanugin
    		Inhibitor
    Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells.
    Demethoxykanugin
  • HY-W017423R
    (-)-Carvone (Standard)
    		Inhibitor
    (-)-Carvone (Standard) is the analytical standard of (-)-Carvone. This product is intended for research and analytical applications. (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.
    (-)-Carvone (Standard)
  • HY-N13926
    Arisugacin F
    		Control
    Arisugacin F, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin F shows no activity against AChE.
    Arisugacin F
  • HY-N13923
    Arisugacin C
    		Inhibitor
    Arisugacin C is an acetylcholinesterase (AChE) inhibitor with an IC50 of 2.5 μM.
    Arisugacin C
  • HY-170775
    AChE-IN-83
    		Inhibitor
    AChE-IN-83 (compound f1) is an inhibitor of AChE that inhibits the growth of nematodes and acetylcholinesterase in rice seeds and is safe for rice seeds. AChE-IN-83 targets Aphelenchoides oryzae with an LC50 value of 19.0 μg/mL (48 hr). AChE-IN-83 can inhibit the population and behavior of rice nematodes in rice seeds, destroy the nematode cuticle, and lead to the production of reactive oxygen species, lipofuscin, and lipids in the nematodes.
    AChE-IN-83
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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