GNPDA1 - glucosamine-6-phosphate deaminase 1 Gene

Homo sapiens

Also known as GPI; HLN; GNP1; GNPI; GNPDA

Gene ID: 10007 | Gene type: protein coding

About GNPDA1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,000,671-142,013,027 (from NCBI)

This gene has 13 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 29.0), urinary bladder (RPKM 18.6) and 24 other tissues.

Summary

Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric Enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

GNPDA1 Products(1)

mRNA	Protein	Name
NM_005471.5	NP_005462.1	glucosamine-6-phosphate isomerase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucosamine-6-phosphate deaminase activity	IDA IDA: Inferred from direct assay	21807125	GOA
enables glucosamine-6-phosphate deaminase activity	IMP IMP: Inferred from mutant phenotype	9438414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in UDP-N-acetylglucosamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	26887390	GOA
involved in generation of precursor metabolites and energy	IMP IMP: Inferred from mutant phenotype	9438414	GOA
involved in glucosamine catabolic process	IMP IMP: Inferred from mutant phenotype	9438414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNPDA1 Protein Structure

Glucosamine_iso

0
100
200
289 a.a.

Protein Preferred Names

Protein Names

glucosamine-6-phosphate isomerase 1

GNPDA 1

GNPDA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNPDA1	P46926	MAGEA11	Homo sapiens	P43364-2	Y2H Prey Pooling	25416956
Intra	GNPDA1	P46926	PRTFDC1	Homo sapiens	Q9NRG1	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05571	GNPDA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GNPDA1	VGNC	VGNC:73101
Rattus norvegicus	GNPDA1	RGD	RGD:1585624
Canis familiaris	GNPDA1	VGNC	VGNC:41331
Bos taurus	GNPDA1	VGNC	VGNC:29476
Felis catus	GNPDA1	VGNC	VGNC:62630
Mus musculus	GNPDA1	MGD	MGI:1347054

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