2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor
  5. Opioid Receptor Isoform
  6. Opioid Receptor Antagonist

Opioid Receptor Antagonist

Opioid Receptor Antagonists (67):

Cat. No. Product Name Effect Purity
  • HY-13274A
    JTC-801 free base
    		Antagonist
    JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM.
  • HY-B1485
    Nalmefene hydrochloride
    		Antagonist
    Nalmefene hydrochloride is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene hydrochloride is used for opioid overdose and alcohol dependence.
  • HY-169822
    5′-Guanidinonaltrindole
    		Antagonist
    5′-Guanidinonaltrindole (GNTI) is a selective kappa opioid receptor antagonist.
  • HY-W778148
    O,O-Diethyl dithiophosphate-13C4 ammonium
    		Antagonist
    O,O-Diethyl dithiophosphate-13C4 (ammonium) is the 13C labeled isotope of O,O-Diethyl dithiophosphate-13C4 (ammonium).
  • HY-123689A
    Samidorphan hydrochloride
    		Antagonist
    Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo.
  • HY-76711S
    Naltrexone-d4
    		Antagonist
    Naltrexone-d4 is deuterium labeled Naltrexone.
  • HY-119733
    BU09059
    		Antagonist
    BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception.