Neurokinin Receptor

Neurokinin Receptor Related Products (163):

By Effects:	Inhibitors (12) Controls (2) Agonists (23) Antagonists (85) Activator (1) Modulators (4)

Cat. No.	Product Name	Effect	Purity

HY-10052

Aprepitant	Inhibitor	99.82%
Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-P0187

Senktide	Agonist	99.85%
Senktide is a tachykinin NK₃ receptor agonist.

HY-14407A

Fosaprepitant dimeglumine	Antagonist	98.02%
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-P0197

Neurokinin A		99.86%
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-16346

Netupitant	Antagonist	99.93%
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-10053S

Maropitant-d₃	Antagonist
Maropitant-d₃ is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-122347

Orvepitant	Antagonist
Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.

HY-14405

Casopitant	Antagonist
Casopitant (GW679769) is a potent, selective, brain-penetrant and orally active neurokinin 1 (NK₁) receptor antagonist. Casopitant antagonizes the emetic effects of Substance P (HY-P0201). Casopitant is also a substrate and weak to moderate inhibitor of CYP3A4. Casopitant is indicated for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

HY-109171

Elinzanetant	Antagonist	99.82%
Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women.

HY-20167A

H-Glu(OtBu)-OtBu hydrochloride		≥98.0%
H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies.

HY-P0242A

Neurokinin B TFA	Agonist	98.59%
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-135108

QWF Peptide	Antagonist	98.15%
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM.

HY-P99143

Anti-Mouse NK1.1 Antibody (PK136)	Inhibitor
Anti-Mouse NK1.1 Antibody is an anti-mouse NK1.1 IgG2a antibody inhibitor derived from host mouse.

HY-P1485A

Substance P(1-7) TFA		99.02%
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

HY-P1012

[Sar9,Met(O2)11]-Substance P	Agonist	98.84%
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-P0236A

Neurokinin A(4-10) TFA	Agonist	98.84%
Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-P0197A

Neurokinin A TFA		99.57%
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P1276A

Men 10376 TFA	Antagonist	98.95%
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P1492

Substance P (7-11)		98.47%
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

HY-P1192

GR-73632	Agonist	99.93%
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

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