2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17367AR
    Atazanavir (sulfate) (Standard)
    Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.
    Atazanavir (sulfate) (Standard)
  • HY-W011249
    Phosphorylcholine chloride calcium salt tetrahydrate
    		100.80%
    Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.
    Phosphorylcholine chloride calcium salt tetrahydrate
  • HY-150526
    EGCG-4″-sulfate
    EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
    EGCG-4″-sulfate
  • HY-10002S1
    Calcitriol-d3
    Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].
    Calcitriol-d<sub>3</sub>
  • HY-101400S1
    Deoxycytidine triphosphate-15N3,d14 dilithium
    Deoxycytidine triphosphate-15N3,d14 (dCTP-15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-<sup>15</sup>N<sub>3</sub>,d<sub>14</sub> dilithium
  • HY-20558R
    D-(+)-Malic acid (Standard)
    D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport.
    D-(+)-Malic acid (Standard)
  • HY-W041895R
    DL-Glutamic acid (Standard)
    DL-Glutamic acid (Standard) is the analytical standard of DL-Glutamic acid. This product is intended for research and analytical applications. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability.
    DL-Glutamic acid (Standard)
  • HY-138031
    Pteroylhexaglutamate
    Pteroylhexaglutamate (PteGlu6) inhibits the T2-phage-induced synthetase by 50% at 0.6 μM in the absence of Mg2+. Pteroylhexaglutamate is a substrate for pteroylpolyglutamate hydrolase, and can be used to monitor the activity of pteroylpolyglutamate hydrolase.
    Pteroylhexaglutamate
  • HY-N0682S1
    Pyridoxine-d2 hydrochloride
    Pyridoxine-d2 (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
    Pyridoxine-d<sub>2</sub> hydrochloride
  • HY-W415798
    Ac4GalNAlk
    Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers.
    Ac4GalNAlk
  • HY-116015
    Dihomo-γ-Linolenic acid methyl ester
    		98.00%
    Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects.
    Dihomo-γ-Linolenic acid methyl ester
  • HY-158569
    SAR114137
    SAR114137 is a highly effective drug with potent biological activity. SAR114137 exhibits altered amorphous content characteristics during physical processing of the crystalline active pharmaceutical ingredient. The amorphous API content of SAR114137 is significantly reduced when processed by different jet grinding techniques. SAR114137 exhibits good chemical stability in pharmaceutical formulations.
    SAR114137
  • HY-Y1718S2
    Tridecanoic acid-d9
    Tridecanoic acid-d9 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
    Tridecanoic acid-d<sub>9</sub>
  • HY-E70063
    alpha-2,3-Sialyltransferase (Phα2,3SiaT)
    alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids.
    alpha-2,3-Sialyltransferase (Phα2,3SiaT)
  • HY-158583
    13-POHSA
    13-POHSA is one of fatty acid esters of hydroxy fatty acids (FAHFAs). 13-POHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration.
    13-POHSA
  • HY-113320R
    Etiocholanolone (Standard)
    Cimbuterol (Standard) is the analytical standard of Cimbuterol. This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic receptor agonist.
    Etiocholanolone (Standard)
  • HY-P2888A
    Bilirubin oxidase, bacillus cereus
    Bilirubin oxidase, bacillus cereus is a multi-copper oxidase that catalyzes the oxidation of bilirubin into biliverdin, as well as other tetrapyrroles, phenols, and aryl diamines. Bilirubin oxidase, bacillus cereus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, bacillus cereus can be used to develop enzyme-based biosensors.
    Bilirubin oxidase, bacillus cereus
  • HY-E70251
    22:6 Coenzyme A
    22:6 Coenzyme A (Docosahexaenoyl coenzyme A triammonium) is a coenzyme that contains 22 carbon atoms and 6 unsaturated bonds. 22:6 Coenzyme A can serve as an acyl substrate and is used in research on the effects of lysophospholipid acyltransferase activities in adipocyte differentiation.
    22:6 Coenzyme A
  • HY-W010388S
    Creatine-13C
    Creatine-13C is the 13C labeled Creatine[1]. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[2].
    Creatine-<sup>13</sup>C
  • HY-Y1667S
    2,6-Dibromophenol-d3
    2,6-Dibromophenol-d3 is the deuterium labeled 2,6-Dibromophenol[1]. 2,6-Dibromophenol is an endogenous metabolite.
    2,6-Dibromophenol-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity