2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Androgen Receptor

Androgen Receptor

Androgen Receptor

Related Products

PDF 1.49 MB

Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W653723R
    N-Nitrosodicyclohexylamine (Standard)
    		Antagonist
    N-Nitrosodicyclohexylamine (Standard) is the analytical standard of N-Nitrosodicyclohexylamine. This product is intended for research and analytical applications. N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein.
    N-Nitrosodicyclohexylamine (Standard)
  • HY-16985S
    Darolutamide-d4
    		Antagonist
    Darolutamide-d4 (ODM-201-d4) is deuterium labeled Darolutamide. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay.
    Darolutamide-d<sub>4</sub>
  • HY-135794R
    11-Ketodihydrotestosterone (Standard)
    		Agonist
    11-Ketodihydrotestosterone (Standard) is the analytical standard of 11-Ketodihydrotestosterone. This product is intended for research and analytical applications. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells.
    11-Ketodihydrotestosterone (Standard)
  • HY-106827S1
    Trimegestone-13C,d3
    		Inhibitor
    Trimegestone-13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
    Trimegestone-<sup>13</sup>C,d<sub>3</sub>
  • HY-114246
    ONC1-13B
    ONC1-13B is a potent androgen receptor (AR) antagonist with the activity of effectively inhibiting PSA expression in prostate cancer cells. ONC1-13B can effectively inhibit PSA expression and prostate cancer cell proliferation under DHT stimulation. ONC1-13B exerts its anti-tumor effect by preventing androgen from binding to AR and its nuclear translocation.
    ONC1-13B
  • HY-W744216
    Trestolone acetate
    		Agonist
    Trestolone acetate is a synthetic anabolic androgenic steroid.
    Trestolone acetate
  • HY-123698
    Mebolazine
    		Agonist
    Mebolazine binds to the androgen receptor and produce androgenic and anabolic activity.
    Mebolazine
  • HY-U00052
    Silandrone
    Silandrone is a synthetic, orally active anabolic-androgenic steroid (AAS).
    Silandrone
  • HY-45509
    TLB 150 Benzoate
    		Modulator
    TLB 150 Benzoate (RAD150) is the modulator for androgen receptor with an IC50 of 0.13 μM.
    TLB 150 Benzoate
  • HY-W653896
    Alternariol-d2
    		Inhibitor
    Alternariol-d2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.
    Alternariol-d<sub>2</sub>
  • HY-B2044R
    Bromopropylate (Standard)
    		Inhibitor
    Bromopropylate (Standard) is the analytical standard of Bromopropylate. This product is intended for research and analytical applications. Bromopropylate is a pesticide with moderate anti-androgenic activities.
    Bromopropylate (Standard)
  • HY-N6660R
    Trisdecanoin (Standard)
    		Inhibitor
    Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics.
    Trisdecanoin (Standard)
  • HY-16985R
    Darolutamide (Standard)
    		Antagonist
    Darolutamide (Standard) is the analytical standard of Darolutamide. This product is intended for research and analytical applications. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay.
    Darolutamide (Standard)
  • HY-B1234R
    Octinoxate (Standard)
    		Modulator
    Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect.
    Octinoxate (Standard)
  • HY-13604R
    Cyproterone acetate (Standard)
    		Antagonist
    Cyproterone acetate (Standard) is the analytical standard of Cyproterone acetate. This product is intended for research and analytical applications. Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors.
    Cyproterone acetate (Standard)
  • HY-13331S2
    Clascoterone-d5-1
    		Antagonist
    Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
    Clascoterone-d<sub>5</sub>-1
  • HY-U00198
    Topterone
    		Antagonist
    Topterone is a topical antiandrogen.
    Topterone
  • HY-U00323
    Carbazole derivative 1
    		Inhibitor
    Carbazole derivative 1 is a carbazole derivative which can be used to reduce androgen or oestrogen levels in mammals, including humans.
    Carbazole derivative 1
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity