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brain conditions

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43

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

10

Natural
Products

12

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172318
    IAMA-6

    		NKCC Neurological Disease
    IAMA-6 is a selective NKCC1 inhibitor with neuroprotective effects. IAMA-6 can be used for the study of brain conditions, including drug-resistant epilepsy (e.g. temporal lobe epilepsy (TLE) and Dravet syndrome (DrS)), autism spectrum disorders (ASD) and Down syndrome (DoS) .
    IAMA-6
  • HY-W010388AS
    Creatine-d3 hydrate

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Creatine-d3 (hydrate) is a deuterium labeled Creatine hydrate. Creatine hydrate is pivotal in energy metabolism of muscle and brain cells, both in physiological and in pathological conditions .
    Creatine-d3 hydrate
  • HY-N0666A
    L-Aspartic acid potassium
    4 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Aspartic acid potassium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd potassium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd potassium commonly used in the study of inflammatory conditions .
    L-Aspartic acid potassium
  • HY-N0666
    L-Aspartic acid
    4 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid
  • HY-N0666C
    L-Aspartic aicd sodium
    4 Publications Verification

    Sodium L-aspartate

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd sodium
  • HY-N0666D
    L-Aspartic aicd disodium
    4 Publications Verification

    Disodium L-aspartate

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd disodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd disodium
  • HY-106110
    OP-2507

    		Prostaglandin Receptor Metabolic Disease
    OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .
    OP-2507
  • HY-N0666CR
    L-Aspartic aicd sodium (Standard)

    Sodium L-aspartate (Standard)

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic aicd sodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd sodium (Standard)
  • HY-N0666DR
    L-Aspartic aicd disodium (Standard)

    Disodium L-aspartate (Standard)

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid disodium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic acid disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic acid disodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd disodium (Standard)
  • HY-101185
    T808

    		Tau Protein Neurological Disease
    T808 is a tau-selective Alzheimer’s PET ligand. T808 is a type of imaging agent used in positron emission tomography (PET) scans. It is a radiotracer that is used to help visualize certain areas of the body, such as the brain, in order to diagnose and monitor various medical conditions .
    T808
  • HY-N0666S
    L-Aspartic acid-13C

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C is a 13C labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C
  • HY-N0666S3
    L-Aspartic acid-15N

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 15N is the 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-15N
  • HY-N0666S2
    DL-Aspartic acid-d3

    		Isotope-Labeled Compounds Endogenous Metabolite Inflammation/Immunology
    DL-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    DL-Aspartic acid-d3
  • HY-N0666S8
    L-Aspartic acid-d3

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-d3
  • HY-127022
    Anisodine

    Daturamine; α-Hydroxyscopolamine

    		 mAChR Calcium Channel Reactive Oxygen Species (ROS) Neurological Disease
    Anisodine (Daturamine) is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine leads to decreased aspartate levels during hypoxia .
    Anisodine
  • HY-N0666S4
    L-Aspartic acid-13C4

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C4
  • HY-127022A
    Anisodine hydrobromide

    Daturamine hydrobromide; α-Hydroxyscopolamine hydrobromide

    		 mAChR Calcium Channel Reactive Oxygen Species (ROS) Neurological Disease
    Anisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia .
    Anisodine hydrobromide
  • HY-N0666AR
    L-Aspartic acid potassium (Standard)

    		Reference Standards Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid (potassium) (Standard) is the analytical standard of L-Aspartic acid (potassium). This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid potassium (Standard)
  • HY-N0666S10
    L-Aspartic acid-C13-1

    [3-13C]Aspartic acid

    		 Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C-1 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-C13-1
  • HY-N0666R
    L-Aspartic acid (Standard)
    1 Publications Verification

    		 Reference Standards Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid (Standard) is the analytical standard of L-Aspartic acid. This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid (Standard)
  • HY-N0666E
    L-Aspartic acid (monocesium)

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid monocesium is the monocesium salt form of L-Aspartic acid (HY-N0666). L-Aspartic aicd monocesium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd monocesium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd monocesium commonly used in the study of inflammatory conditions .
    L-Aspartic acid (monocesium)
  • HY-N0666S9
    L-Aspartic acid-15N,d3

    		Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    L-Aspartic acid- 15N,d3 is the deuterium and 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-15N,d3
  • HY-N0666B
    Aspartic acid calcium
    4 Publications Verification

    Calcium L-aspartate

    		 Endogenous Metabolite Inflammation/Immunology
    Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic aicd calcium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd calcium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd calcium commonly used in the study of inflammatory conditions .
    Aspartic acid calcium
  • HY-B0985A
    Phenazopyridine
    2 Publications Verification

    		 TRP Channel Neurological Disease
    Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .
    Phenazopyridine
  • HY-N0666S6
    L-Aspartic acid-1,4-13C2

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid-1,4- 13C2 is the 13C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-1,4-13C2
  • HY-N0666S1
    L-Aspartic acid-13C4,15N

    		Endogenous Metabolite Cardiovascular Disease
    L-Aspartic acid- 13C4, 15N is the 13C-labeled and 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C4,15N
  • HY-144874
    AZ3391

    		PARP Neurological Disease Cancer
    AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23) .
    AZ3391
  • HY-B0985
    Phenazopyridine hydrochloride
    2 Publications Verification

    		 TRP Channel Neurological Disease
    Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .
    Phenazopyridine hydrochloride
  • HY-19454
    CP-464709

    		GHSR Cardiovascular Disease
    CP-464709 is a Ghrelin receptor agonist that can penetrate the blood-brain barrier. CP-464709 causes an increase in blood pressure by activating pre sympathetic neurons in the spinal cord. CP-464709 causes biphasic blood pressure response when administered intravenously, while intrathecal administration only causes pressor. CP-464709 can be used for research on cardiovascular conditions .
    CP-464709
  • HY-N0666S7
    L-Aspartic acid-1,4-13C2,15N

    		Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    L-Aspartic acid-1,4- 13C2, 15N is the 13C- and 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-1,4-13C2,15N
  • HY-N0666S5
    L-Aspartic acid-13C4,15N,d3

    		Isotope-Labeled Compounds Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C4, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C4,15N,d3
  • HY-108615
    CP-316819

    GPi 819

    		 Phosphorylase Endocrinology
    CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC50 values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents .
    CP-316819
  • HY-151369
    AV123

    		RIP kinase Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases .
    AV123
  • HY-B0985R
    Phenazopyridine hydrochloride (Standard)

    		Reference Standards TRP Channel Neurological Disease
    Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .
    Phenazopyridine hydrochloride (Standard)
  • HY-161461
    E234G HYPE-IN-1

    		Amylases Neurological Disease
    E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes .
    E234G HYPE-IN-1
  • HY-136258
    nAChR agonist CMPI hydrochloride

    		nAChR Neurological Disease
    nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity .
    nAChR agonist CMPI hydrochloride
  • HY-15076
    SPD-502 sodium

    NS-1209 sodium

    		 iGluR Neurological Disease
    SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity .
    SPD-502 sodium
  • HY-15074
    SPD-502

    NS-1209

    		 iGluR Neurological Disease
    SPD-502 is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity .
    SPD-502
  • HY-176546
    NK3R-IN-2

    		Neurokinin Receptor Endocrinology
    NK3R-IN-2 is an orally active NK3R inhibitor with an IC50 of 330.50 nM for human NK3R. NK3R-IN-2 can pass through the blood-brain barrier. NK3R-IN-2 has excellent NK3R binding affinity (IC50 = 87.31 nM) in CHO-K1 cells. NK3R-IN-2 effectively inhibits the level of luteinizing hormone (LH). NK3R-IN-2 can be used for research on hormone related conditions .
    NK3R-IN-2
  • HY-P1047
    β-Sheet Breaker Peptide iAβ5

    [Pro18, Asp21] β-Amyloid (17-21)

    		 Amyloid-β Neurological Disease
    β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
    β-Sheet Breaker Peptide iAβ5
  • HY-147423
    Zandatrigine
    1 Publications Verification

    NBI-921352; XEN901

    		 Sodium Channel Neurological Disease
    Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel NaV1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of NaV1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as NaV1.1 and NaV1.2, and has minimal effect on NaV1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study NaV1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy .
    Zandatrigine
  • HY-P99146
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

    		CD3 Infection Neurological Disease Inflammation/Immunology Cancer
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer .
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
  • HY-161972
    ZX782

    		PROTACs Glutathione Peroxidase Ferroptosis Cancer
    ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination . ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).
    ZX782

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