Xanthine Oxidase Inhibitor

Xanthine Oxidase Inhibitors (97):

Cat. No.	Product Name	Effect	Purity

HY-146297

Xanthine oxidoreductase-IN-2	Inhibitor
Xanthine oxidoreductase-IN-2 (Compound IVa) is a xanthine oxidoreductase (XOR) inhibitor with the IC₅₀ of 7.2 nM. Xanthine oxidoreductase-IN-2 shows hypouricemic effects in mice.

HY-14874S

Topiroxostat-d₄	Inhibitor
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].

HY-161455

Xanthine oxidase-IN-13	Inhibitor
Xanthine oxidase-IN-13 (Compound 10) is a selective xanthine oxidase inhibitor (IC₅₀: 149.56 μM for bovine xanthine oxidase). Xanthine oxidase-IN-13 can be used for research of inflammatory arthritis.

HY-155123

Antioxidant agent-13	Inhibitor
Antioxidant agent-13 (Compound 5f) is an antioxidant agent. Antioxidant agent-13 inhibits DPPH and FRAP with IC₅₀s of 80.33 and 85.69 μM. Antioxidant agent-13 also inhibits LOX and XO enzymes with IC₅₀s of 16.85 and 23.01 μM.

HY-162961

Xanthine oxidase-IN-16	Inhibitor
Xanthine oxidase-IN-16 is potent and orally active xanthine oxidase (XO) inhibitor with an IC₅₀ of 102 nM. Xanthine oxidase-IN-16 shows significant efficacy in hyperuricemia rats.

HY-N0196A

Baicalein hydrate	Inhibitor
Baicalein hydrate (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is a xanthine oxidase inhibitor with an IC₅₀ value of 3.12 μM.

HY-116433

Nequinate	Inhibitor
Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.

HY-N9324

Ilexoside O	Inhibitor
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC₅₀=53.05 μM).

HY-162882

CC15009	Inhibitor
CC15009 is a xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ value of 0.237 nM. CC15009 can inhibit the oxidative subtype of XOR, thereby reducing the production of the byproduct ROS and exhibiting antioxidant activity. CC15009 has demonstrated a good dose-dependent uric acid-lowering effect in two different mouse models of hyperuricemia induced by XOR substrates.

HY-129889

Febuxostat acyl glucuronide	Inhibitor
Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor.

HY-N7150

Tricetin 3',4',5'-trimethyl ether	Inhibitor
Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) is a flavone glucoside, that can be isolated the flowers of Chrysanthemum sinensea. Tricetin 3',4',5'-trimethyl ether displays xanthine oxidase competitive-type inhibitory activity, with an IC₅₀ of 0.51 μM and a K_i of 0.37 μM.

HY-N3906

Fraxamoside	Inhibitor
Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.

HY-N10863

Aurantiamide benzoate	Inhibitor
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM.

HY-N0814R

Phytic acid (Standard)	Inhibitor
Phytic acid (Standard) is the analytical standard of Phytic acid. This product is intended for research and analytical applications. Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-151973

Xanthine oxidoreductase-IN-3	Inhibitor
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.

HY-144456

Xanthine oxidase-IN-5	Inhibitor
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.

HY-14268S1

Febuxostat-d₇	Inhibitor
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-141508

Flazin	Inhibitor
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor.

HY-N7397

Forsythoside F	Inhibitor
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.

HY-156360

Xanthine oxidase-IN-12	Inhibitor
Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC₅₀ of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS.

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