2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRP Channel Isoform
  6. TRP Channel Antagonist

TRP Channel Antagonist

TRP Channel Antagonists (63):

Cat. No. Product Name Effect Purity
  • HY-16935S
    Mavatrep-d6
    		Antagonist
    Mavatrep-d6 (JNJ-39439335-d6) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain.
  • HY-113018
    Ibuprofen acyl-β-D-glucuronide
    		Antagonist
    Ibuprofen acyl-β-D-glucuronide (Ibuprofen glucuronide) is a selective TRPA1 antagonis. Ibuprofen acyl-β-D-glucuronide reduces AITC-evoked calcium response with an IC50 value of 60μM.
  • HY-U00330
    TRPV antagonist 1
    		Antagonist
    TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM.