2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel
  5. Nav1.8 Isoform

Nav1.8

 

Nav1.8 Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-P5943
    Pterinotoxin-1
    		Inhibitor
    Pterinotoxin-1 is a sodium channel inhibitor peptide toxin.
  • HY-160592
    Nav1.8-IN-11
    		Inhibitor
    Nav1.8-IN-11 (Example 1) is a Nav1.8 channel inhibitor with a IC50 value of 0.1 nM. Nav1.8-IN-11 can be used in the study of pain disorders.
  • HY-161572
    Nav1.8-IN-13
    		Inhibitor
    Nav1.8-IN-13 (compound 16) is a Nav1.8 inhibitor (pIC50=7.9).
  • HY-P1681
    GpTx-1
    		Antagonist
    GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively.
  • HY-P5811
    Ceratotoxin-1
    		Inhibitor
    Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1.