Serotonin Transporter

5-HTT; SERT; SLC6A4

Serotonin Transporter

Related Products

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (225)
Antibodies (3)

By Effects:	Controls (3) Ligand (1) Inhibitors (197) Agonist (1) Antagonists (2) Activators (2) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0457AR

Clomipramine (Standard)	Inhibitor
Clomipramine (Standard) is the analytical standard of Clomipramine. This product is intended for research and analytical applications. Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC₅₀ value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).

HY-15414S2

Vortioxetine-d₄
Vortioxetine-d₄ (Lu AA 21004-d₄) is the deuterium labeled Vortioxetine (HY-15414). Vortioxetine is an antagonist of 5-HT3A and 5-HT7 receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (K_i: 15 nM, 33 nM).

HY-B0168

Milnacipran	Inhibitor
Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.

HY-B0304R

Dapoxetine (Standard)	Inhibitor
Dapoxetine (Standard) is the analytical standard of Dapoxetine. This product is intended for research and analytical applications. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE).

HY-14262R

Vilazodone (Standard)	Inhibitor
Vilazodone (Standard) is the analytical standard of Vilazodone. This product is intended for research and analytical applications. Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders.

HY-17385R

Atomoxetine (hydrochloride) (Standard)	Inhibitor
Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.

HY-117512

UWA-101 hydrochloride	Inhibitor
UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC₅₀ values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease.

HY-N0173R

Cinchonidine (Standard)	Inhibitor
Cinchonidine (Standard) is the analytical standard of Cinchonidine. This product is intended for research and analytical applications. Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities.

HY-W290532

(Rac)-Dapoxetine hydrochloride	Inhibitor
(Rac)-Dapoxetine hydrochloride is a racemate of Dapoxetine hydrochloride (HY-B0304A). Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).

HY-W013776

meta-Fluoxetine hydrochloride	Control
meta-Fluoxetine hydrochloride is the isomer of Fluoxetine hydrochloride (HY-B0102A). meta-Fluoxetine hydrochloride is a weak serotonin selective reuptake inhibitor (SSRI).

HY-101612

SPD-473 citrate	Inhibitor	99.80%
SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.

HY-101684

Nitroxazepine	Inhibitor
Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.

HY-19417A

Wf-516	Inhibitor
Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with K_i of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.

HY-B0161S3

Duloxetine-d₅ oxalate	Inhibitor
Duloxetine-d₅ (oxalate) ((S)-Duloxetine-d₅ (oxalate)) is deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

HY-14261R

Vilazodone (Hydrochloride) (Standard)	Inhibitor
Vilazodone (Hydrochloride) (Standard) is the analytical standard of Vilazodone (Hydrochloride). This product is intended for research and analytical applications. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT_1A receptor partial agonist.

HY-W725113

N-Nitroso fluoxetine	Control
N-Nitroso fluoxetine is a derivative of Fluoxetine (HY-B0102). Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-167894

DA-8031	Inhibitor
DA-8031 is a selective and orally active serotonin reuptake inhibitor. DA-8031 can be used for the research of premature ejaculation (PE).

HY-B0304AR

Dapoxetine (hydrochloride) (Standard)	Inhibitor
Dapoxetine (hydrochloride) (Standard) is the analytical standard of Dapoxetine (hydrochloride). This product is intended for research and analytical applications. Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).

HY-15414S1

Vortioxetine-d₆	Inhibitor
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM).

HY-125932A

9β-Debilon	Modulator
9β-Debilon is a sesquiterpenoid compound found in Nardostachys chinensis and may possess SERT regulatory activity. Structurally, 9β-Debilon is a diastereomer of Debilon (HY-125932). 9β-Debilon holds potential for research into neurological disorders.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Serotonin Transporter

Serotonin Transporter

Serotonin Transporter Related Products (225)

Antibodies (3)

Serotonin Transporter Related Products (225):