2. Signaling Pathways
  3. GPCR/G Protein
  4. Platelet-activating Factor Receptor (PAFR)

Platelet-activating Factor Receptor (PAFR)

The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in both normal physiological and numerous pathophysiological processes. PAFR responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. Stimulation of the PAFR via binding of platelet-activating factor (PAF) elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. PAF is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118779
    Rhazimine
    		Inhibitor
    Rhazimine is an indole alkaloid that is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation.
    Rhazimine
  • HY-N12707
    Kadsurenin C
    		Antagonist
    Kadsurenin C (compound 1) is a neolignan that can be isolated from the aerial part of Piper kadsura with anti-inflammation activity. Kadsurenin C exhibits significant PAF (Platelet Activating Factor) antagonistic activity with IC50 value of 5.1 μM.
    Kadsurenin C
  • HY-141612
    Pyrrolidino PAF C-16
    		Activator
    Pyrrolidino PAF C-16 is a platelet activating factor ( PAF ) analogue that has hypohematic effects.
    Pyrrolidino PAF C-16
  • HY-101654
    Rocepafant
    		Antagonist
    Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research.
    Rocepafant
  • HY-N8218
    Homoeriodictyol 7-O-β-D-glucoside
    Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC50 of 0.8 μM.
    Homoeriodictyol 7-O-β-D-glucoside
  • HY-105198
    Lexipafant
    Lexipafant is a platelet-activating factor (PAF) antagonist that inhibits the inflammatory response and is used in the research of acute pancreatitis.
    Lexipafant
  • HY-121394
    L-659,989
    		Agonist
    L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist.
    L-659,989
  • HY-106899A
    (rel)-MK 287
    		Control
    (rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287, a tetrahydrofuran analog, potently inhibited [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with Kis of 6.1 nM, 3.2 nM and 5.49 nM, respectively. MK 287 inhibits PAF-induced lethality in mice and PAF-induced bronchoconstriction in guinea pigs.
    (rel)-MK 287
  • HY-10164
    E-​6123
    E-6123 is a platelet-activating factor (PAF) receptor antagonist.
    E-​6123
  • HY-121007
    Bepafant
    		Antagonist
    Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.
    Bepafant
  • HY-101675
    Setipafant
    Setipafant is a platelet-activating factor (PAF) antagonist.
    Setipafant
  • HY-106833A
    SDZ-62-434
    		Antagonist
    SDZ-62-434 is a platelet-activating factor (PAF) antagonist. SDZ-62-434 has antiproliferative activity in human solid and haematological malignancies.
    SDZ-62-434
  • HY-118019
    Scandenolide
    Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes.
    Scandenolide
  • HY-134101
    2-O-Ethyl PAF C-16
    2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM.
    2-O-Ethyl PAF C-16
  • HY-126551
    Butenoyl-PAF
    		Agonist
    Butenoyl-PAF is a phospholipid analog of platelet activating factor (PAF-like) that is generated in oxidized low-density lipoprotein (DLDR). Butenoyl-PAF can activate cells that express human PAF receptors, such as neutrophils, monocytes, and platelets, and it stimulates an increase in intracellular calcium ion concentration.
    Butenoyl-PAF
  • HY-167719
    Dersalazine
    		Inhibitor
    Dersalazine (UR-12746 free base) is an inhibitor of platelet-activating factor, exhibiting intestinal anti-inflammatory activity and potential efficacy in treating ulcerative colitis.
    Dersalazine
  • HY-123399
    Ro 19-1400
    		Antagonist
    Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release.
    Ro 19-1400
  • HY-N1620
    1-Cinnamoylpyrrolidine
    		Inhibitor
    1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM.
    1-Cinnamoylpyrrolidine
  • HY-124887
    L 651142
    		Antagonist
    L 651142 is a weak platelet activating factor (PAF) receptor antagonist. L 651142 inhibits the binding of [3H]PAF to rabbit platelet, human platelet or human lung membranes with Kis of 0.839 μM, 1.82 μM, 3.64 μM, respectively.
    L 651142
  • HY-106038
    Acopafant
    		Antagonist
    Acopafant (Dacopafant; RP 55778) is a potent platelet-activating factor antagonist. Acopafant inhibits the induction of human immunodeficiency virus (HIV) expression in chronically infected cells. Acopafant has the potential for the research of HIV infection.
    Acopafant
Cat. No. Product Name / Synonyms Application Reactivity