2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

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Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114672
    MBCQ
    		Inhibitor 99.80%
    MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM). MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE.
    MBCQ
  • HY-90009S
    Tadalafil-d3
    		Inhibitor 99.40%
    Tadalafil-d3 is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
    Tadalafil-d<sub>3</sub>
  • HY-117604
    THPP-1
    		Inhibitor 98.75%
    THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.
    THPP-1
  • HY-100650
    Carbodenafil
    		Inhibitor 99.63%
    Carbodenafil is a Sildenafil (UK-92480) related compound found in health foods. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Carbodenafil
  • HY-100530B
    Sp-cAMPS
    		Inhibitor
    Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM.
    Sp-cAMPS
  • HY-I0636
    (R)-Apremilast
    		Control 99.99%
    (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.
    (R)-Apremilast
  • HY-116100A
    HA155
    		Inhibitor 98.00%
    HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM.
    HA155
  • HY-112555
    PDE7-IN-2
    		Inhibitor ≥99.0%
    PDE7-IN-2 (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 µM. PDE7-IN-2 has the potential for the research of parkinson’s disease.
    PDE7-IN-2
  • HY-18078
    PQ-10
    		Inhibitor 99.77%
    PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia.
    PQ-10
  • HY-11070
    MK-0952
    		Inhibitor 99.71%
    MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study.
    MK-0952
  • HY-N2913
    Ayanin
    		Inhibitor 98.18%
    Ayanin is a bioflavonoid isolated from Psychotria serpens. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for the study of respiratory disease,such as allergic asthma et al.
    Ayanin
  • HY-136350B
    (S)-BRD9500
    		Control 99.67%
    (S)-BRD9500 is the isomer of BRD9500 (HY-136350), and can be used as an experimental control. BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.
    (S)-BRD9500
  • HY-143254
    Enpp-1-IN-10
    		Inhibitor 98.64%
    Enpp-1-IN-10 (compound 1) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 3.866 μM. Enpp-1-IN-10 can be used for researching anticancer.
    Enpp-1-IN-10
  • HY-15025S2
    Sildenafil-d3N-1
    		99.47%
    Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Sildenafil-d<sub>3</sub>N<sub>-1
  • HY-108619
    Gisadenafil besylate
    		Inhibitor ≥99.0%
    Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP).
    Gisadenafil besylate
  • HY-101693A
    Senazodan hydrochloride
    		Inhibitor 99.84%
    Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III.
    Senazodan hydrochloride
  • HY-13344A
    PF-8380 hydrochloride
    		Inhibitor 98.59%
    PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
    PF-8380 hydrochloride
  • HY-U00208
    Prinoxodan
    		Inhibitor 99.83%
    Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.
    Prinoxodan
  • HY-50865
    PDE-9 inhibitor
    		Inhibitor 99.79%
    PDE-9 inhibitor is useful for neurodegenerative diseases.
    PDE-9 inhibitor
  • HY-131100
    Homo Sildenafil
    		Inhibitor 99.32%
    Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
    Homo Sildenafil
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

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