2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  4. PPAR
  5. PPAR Isoform
  6. PPAR Inhibitor

PPAR Inhibitor

PPAR Inhibitors (46):

Cat. No. Product Name Effect Purity
  • HY-155062
    IR-251
    		Inhibitor
    IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis.
  • HY-RS10926
    Pparg Mouse Pre-designed siRNA Set A
    		Inhibitor

    Pparg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pparg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS10923
    Ppard Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ppard Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppard gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-N2302R
    Fucoxanthin (Standard)
    		Inhibitor
    Fucoxanthin (Standard) is the analytical standard of Fucoxanthin. This product is intended for research and analytical applications. Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.
  • HY-RS10925
    PPARG Human Pre-designed siRNA Set A
    		Inhibitor

    PPARG Human Pre-designed siRNA Set A contains three designed siRNAs for PPARG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-N7661
    4β-Hydroxywithanolide E
    		Inhibitor
    4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression.
  • HY-RS10920
    Ppara Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ppara Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppara gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS10921
    Ppara Rat Pre-designed siRNA Set A
    		Inhibitor

    Ppara Rat Pre-designed siRNA Set A contains three designed siRNAs for Ppara gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-122959
    Kihadanin B
    		Inhibitor
    Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
  • HY-N2388R
    Auraptene (Standard)
    		Inhibitor
    Auraptene (Standard) is the analytical standard of Auraptene. This product is intended for research and analytical applications. Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis.
  • HY-RS10927
    Pparg Rat Pre-designed siRNA Set A
    		Inhibitor

    Pparg Rat Pre-designed siRNA Set A contains three designed siRNAs for Pparg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-Y0078R
    Cinnamyl Alcohol (Standard)
    		Inhibitor 99.38%
    Cinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohol. This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.
  • HY-RS10922
    PPARD Human Pre-designed siRNA Set A
    		Inhibitor

    PPARD Human Pre-designed siRNA Set A contains three designed siRNAs for PPARD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-13766
    Timcodar
    		Inhibitor
    Timcodar is a macrolide agent, and studies have shown that during adipogenesis, timcodar can significantly inhibit fat accumulation, with an effect similar to that of rapamycin. However, unlike rapamycin, timcodar does not cause immunosuppression and glucose resistance. In addition, timcodar can effectively inhibit the adipogenic transcriptional regulators PPAR?? and C/EBP??, thereby inhibiting genes involved in fat accumulation. These studies lay the foundation for timcodar as a potential anti-obesity therapy, as obesity is becoming a global epidemic.
  • HY-N0182S3
    Fisetin-d5
    		Inhibitor
    Fisetin-d5 is a deuterated labeled Fisetin. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-N0265R
    Asperosaponin VI (Standard)
    		Inhibitor
    Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the BMP-2/p38 and ERK1/2 signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities.
  • HY-N15415
    Zaluzanin C
    		Inhibitor
    Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes.
  • HY-Y0078S
    Cinnamyl Alcohol-d5
    		Inhibitor
    Cinnamyl Alcohol-d5 is deuterated labeled 3-Methyl-2-cyclopenten-1-one (HY-W013014). 3-Methyl-2-cyclopenten-1-one is an endogenous metabolite.
  • HY-N11924
    Foenumoside B
    		Inhibitor
    Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates AMPK signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases.
  • HY-100277R
    Mifobate (Standard)
    		Inhibitor
    Mifobate (Standard) is the analytical standard of Mifobate. This product is intended for research and analytical applications. Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.