OX₂ Receptor

OX₂ Receptor Related Products (42):

By Type:	Pan (12) Selective (14)
By Effects:	Inhibitor (1) Agonists (20) Antagonists (21)

Cat. No.	Product Name	Effect	Purity

HY-109012A

Seltorexant hydrochloride	Antagonist	99.90%
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

HY-139559

Vornorexant	Antagonist	99.66%
Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia research research.

HY-101834

ACT-462206	Antagonist	99.60%
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC₅₀s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research.

HY-137440A

Firazorexton hydrate	Agonist	99.94%
Firazorexton hydrate (TAK-994) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton hydrate can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Agonist	98.31%
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1349

Orexin B, rat, mouse	Agonist
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1349A

Orexin B, rat, mouse TFA	Agonist
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.

HY-108683

ACT-335827	Antagonist	≥98.0%
ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC₅₀ values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders.

HY-138695

Orexin 2 Receptor Agonist 2	Agonist	98.06%
Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16.

HY-137452

Suntinorexton	Agonist	98.66%
Suntinorexton (TAK-861) is an orally active and selective OX2R agonist with an EC₅₀ of 2.5 nM. Suntinorexton ameliorates narcolepsy-like phenotypes.

HY-134188

JNJ-54717793	Antagonist	98.06%
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders.

HY-100452A

TCS-OX2-29 hydrochloride	Antagonist
TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX₂R) antagonist with an IC₅₀ value of 40 nM and a pK_I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX₂ over OX₁.

HY-162235

CVN766	Antagonist
CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC₅₀ values of 8 nM and >10 μM for OX1R and OX2R, respectively. CVN766 can be used for study schizophrenia.

HY-162712

OX-201	Agonist
OX-201 is a selective agonist for OX2R with an EC₅₀ of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a manner dependent on neuronal activity and are cleared from the brain via lymphatic pathways. The outflow of pathological proteins to the ISF is related to the arousal state of neurons. OX-201 can induce neuronal awakening and promote the release of tau into the hippocampal ISF. Although OX-201 does not alter hippocampal tau levels, it has potential applications for Alzheimer's disease (AD) associated with sleep/wake rhythm disturbances.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Agonist
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-161567

OX2R-IN-3	Antagonist
OX2R-IN-3 (Compound 53) is an orally active type 2 orexin receptor (OX2R) agonist (EC₅₀<100 nM.).

HY-P1341A

OXA(17-33) TFA	Agonist
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-146517

Orexin receptor antagonist 4	Antagonist
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC₅₀ of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC₅₀ of 295 nM) (WO2018206959A1; example 1).

HY-10805S

Almorexant-¹³C,d₃	Antagonist
Almorexant-¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

HY-149014

OX2R-IN-1	Inhibitor
OX₂R-IN-1 (compound 15) is a low cytotoxicity profile OX₂R-IN-1 antagonist (a potential OX2R binder) with an IC₅₀ value of 484 μM. OX₂R-IN-1 (compound 15) can cross the BBB into the brain with a short half-life.

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