Opioid Receptor Antagonist

Opioid Receptor Antagonists (67):

Cat. No.	Product Name	Effect	Purity

HY-N2304A

Methyl-6-alpha-Naltrexol	Antagonist
Methyl-6-alpha-Naltrexol is a metabolite of Methylnaltrexone (MNTX). Methylnaltrexone is a selective mu-opioid receptor antagonist and functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.

HY-107749

ML 190	Antagonist	98.2%
ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC₅₀ of 120 nM and an EC₅₀ of 129 nM, respectively.

HY-10486

JDTic	Antagonist
JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors.

HY-156614

Icalcaprant	Antagonist
Icalcaprant is a kappa-opioid receptor antagonist.

HY-136586

Loperamide phenyl	Antagonist
Loperamide phenyl is an impurity of Loperamide (HY-B0418A). Loperamide is an opioid receptor agonist.

HY-114452A

LY2940094 tartrate	Antagonist
LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (K_i=0.105 nM) and antagonist potency (K_b=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models.

HY-76711R

Naltrexone (Standard)	Antagonist
Naltrexone (Standard) is the analytical standard of Naltrexone. This product is intended for research and analytical applications. Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system.

HY-76657AR

Alvimopan (dihydrate) (Standard)	Antagonist
Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus.

HY-P5892

β-Endorphin (1-27) (human)	Antagonist
β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with K_is of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia.

HY-P1316

Ac-RYYRWK-NH2	Antagonist
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [³H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a K_d of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors.

HY-149387

D3R/MOR antagonist 2	Antagonist
D3R/MOR antagonist 2 (Compound 121) is a D3R/MOR antagonist (K_i: 361 nM and 85.2 nM respectively). D3R/MOR antagonist 2 has the potential to produce analgesic effects through MOR partial agonism, reduce opioid-misuse liability via D3R antagonism.

HY-P2429

N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu	Antagonist
N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu is a compound that can antagonize the δ-opioid receptor and the action of [D-Pen2,D-Pen?] enkephalin in vivo. Its antagonistic effect can be verified by specific behavioral experiments.

HY-P1320A

[Nphe1]Nociceptin(1-13)NH2 TFA	Antagonist
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pK_i=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA₂=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent.

HY-162669

Mu opioid receptor antagonist 8	Antagonist
Mu opioid receptor antagonist 8 (368) is a μ-opioid receptor antagonist. Mu opioid receptor antagonist 8 (368) significantly inhibits met-enkephalin-induced µOR activation of G_i.

HY-158236

ORL1 antagonist 2	Antagonist
ORL1 antagonist 2 (1B) is an opioid receptor-Like 1 (ORL1) antagonist, usd in P-glycoprotein (P-gp) research.

HY-P2669

Boc-YPGFL(O-tBu)	Antagonist
Boc-YPGFL(O-tBu) is a selective δ opioid receptor (DOR) peptide antagonist.

HY-158290

Natrexone/BSA	Antagonist
Natrexone/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-167946

CP-866087	Antagonist
CP-866087 is a new, highly effective, and selective antagonist of the mu-opioid receptor designed for exploring female sexual dysfunction.

HY-13222A

BAN ORL 24 free base	Antagonist
BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with K_I value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic.

HY-107745

SDM25N hydrochloride	Antagonist
SDM25N hydrochloride, a δ-opioid receptor antagonist, is a potent DENV inhibitor. SDM25N hydrochloride targets the viral NS4B protein and restricts genomic RNA replication.

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