Opioid Receptor

Opioid Receptor Related Products (349):

By Effects:	Controls (8) Inhibitors (12) Ligands (5) Agonists (152) Antagonists (67) Activators (11) Modulators (13)

Cat. No.	Product Name	Effect	Purity

HY-120949

(1R,2R)-U-50488 hydrochloride	Agonist	99.14%
(1R,2R)-U-50488 hydrochloride is the absolute stereochemistry of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a selective κ opioid receptor (KOR) agonist.

HY-P1470

[Leu5]-Enkephalin, amide	Agonist
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

HY-101231

ICI-204448		98.68%
ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes.

HY-126941

Hecogenin acetate		99.30%
Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors.

HY-101079

BRL 52537 hydrochloride	Agonist	98.14%
BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with K_is of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage.

HY-P1170

N-terminally acetylated Leu-enkephalin	Agonist	99.49%
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-15997C

(±)-U-50488 hydrate hydrochloride	Agonist	99.76%
(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist.

HY-16765A

Axelopran sulfate	Antagonist
Axelopran sulfate is an opioid receptor antagonist with pKi values of 9.8, 8.8 and 9.9 for human recombinant μ and δ receptors and guinea pig κ receptor, respectively.

HY-118416

BMS-986124	Antagonist	99.00%
BMS-986124 is a μ-opioid receptor silent allosteric modulator (μ-SAMs). BMS-986124 antagonizes positive allosteric modulator effect of BMS-986122 (µ-OR PAM).

HY-B0418AS

Loperamide-d₆ hydrochloride	Agonist	99.07%
Loperamide-d₆ (hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is an opioid receptor agonist for the treatment of diarrhea[1].

HY-19627

Naldemedine	Antagonist
Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC₅₀=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. Naldemedine is predicted to bind to 3CL^pro encoded by SARS-CoV2 genome.

HY-P0318

Hemorphin-7	Activator
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P1779

β-Casomorphin (1-5), bovine		99.62%
β-Casomorphin (1-5), bovine is a peptide of bovine β-Casomorphin.

HY-P3445A

Anrikefon acetate	Agonist	99.25%
Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist with analgesic effect.

HY-107384

Asimadoline	Agonist	99.36%
Asimadoline (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC₅₀s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS).

HY-107743

Naloxone benzoylhydrazone	Modulator	≥99.0%
Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect.

HY-A0118

Naloxegol	Antagonist
Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.

HY-14157

ADL-5747	Agonist	99.82%
ADL-5747 is a selective and orally active agonist of the δ-opioid receptor (DOR). By binding to the δ-opioid receptors, ADL-5747 activates these receptors, thereby playing a role in pain management pathways. ADL-5747 can be used for research into pain management mechanisms.

HY-134189A

EST73502 monohydrochloride	Agonist	99.58%
EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K_is of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity.

HY-P1742

Gluten Exorphin B5	Agonist	98.23%
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats.

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