2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169822
    5′-Guanidinonaltrindole
    		Antagonist
    5′-Guanidinonaltrindole (GNTI) is a selective kappa opioid receptor antagonist.
    5′-Guanidinonaltrindole
  • HY-158967
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride is a utopioid.
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride
  • HY-168350
    Chlorphine
    Chlorphine is a neuroactive halogenated opioid analog.
    Chlorphine
  • HY-150332
    N-Propionitrile Chlorphine hydrochloride
    N-Propionitrile Chlorphine hydrochloride is structurally similar to known opioids.
    N-Propionitrile Chlorphine hydrochloride
  • HY-W725198
    3,4-Difluoro U-49900 hydrochloride
    3,4-Difluoro U-49900 hydrochloride is an opioid.
    3,4-Difluoro U-49900 hydrochloride
  • HY-W683876
    Desmethylmoramide
    Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents.
    Desmethylmoramide
  • HY-120846
    CHIR 4531
    		Inhibitor
    CHIR 4531, a trimer peptide, is a opiate ligand that binds to the mu-opiate receptor with a Ki of 6 nM.
    CHIR 4531
  • HY-168366
    R-6890
    R-6890 is an opiate compound with analgesic potencies.
    R-6890
  • HY-B0557R
    Bisacodyl (Standard)
    		Inhibitor
    Bisacodyl (Standard) is the analytical standard of Bisacodyl. This product is intended for research and analytical applications. Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect.
    Bisacodyl (Standard)
  • HY-120045A
    DuP 747 hydrochloride
    DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration.
    DuP 747 hydrochloride
  • HY-W318577
    4-Hydroxy-1-(2-phenylethyl)piperidine
    		Control
    4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).
    4-Hydroxy-1-(2-phenylethyl)piperidine
  • HY-150341
    Ortho-methyl 4-anilino-1-boc-piperidine
    Ortho-methyl 4-anilino-1-boc-piperidine is a precursor in the synthesis of a compound.
    Ortho-methyl 4-anilino-1-boc-piperidine
  • HY-123582
    CP-866,087
    CP-866,087 is a novel, potent and selective μ-opioid receptor antagonist with activity to inhibit opioid effects. CP-866,087 has shown promising preclinical efficacy data in disease models associated with alcohol consumption. CP-866,087 has also been used to study female sexual dysfunction.
    CP-866,087
  • HY-101392A
    Harmane hydrochloride
    		Inhibitor
    Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).
    Harmane hydrochloride
  • HY-168352
    Orphine
    		Ligand
    Orphine is an opioid compound. Orphine can enhance the antinociceptive effects in mice that are mitigated by Naloxone (HY-17417).
    Orphine
  • HY-N3072
    Picraline
    Picraline is a natural alkaloid that targets opioid receptors with binding affinities with Ki values of 132 μM, 2.38 μM and 98.8 μM for μOR, κOR and δOR, respectively.
    Picraline
  • HY-W326260
    AH 8529
    AH 8529 is an orally active opioid compound. AH 8529 has an analgesic effect.
    AH 8529
  • HY-W778148
    O,O-Diethyl dithiophosphate-13C4 ammonium
    		Antagonist
    O,O-Diethyl dithiophosphate-13C4 (ammonium) is the 13C labeled isotope of O,O-Diethyl dithiophosphate-13C4 (ammonium).
    O,O-Diethyl dithiophosphate-<sup>13</sup>C<sub>4</sub> ammonium
  • HY-156993
    NOP agonist-2
    		Agonist
    NOP agonist-2 is a selective NOP agonist.
    NOP agonist-2
  • HY-168826
    N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride
    N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride is structurally similar to known opioids.
    N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

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