2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin
  5. Microtubule/Tubulin Inhibitor

Microtubule/Tubulin Inhibitor

Microtubule/Tubulin Inhibitors (598):

Cat. No. Product Name Effect Purity
  • HY-107492
    Ethaboxam
    		Inhibitor
    Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
  • HY-168326
    Antiproliferative agent-64
    		Inhibitor
    Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM.
  • HY-W470415
    Alfalone
    		Inhibitor
    Alfalone (compound 9ia) is an antimitotic agent. Alfalone causes cleavage arrest and initiates the formation of tuberculate eggs.
  • HY-79128S1
    Fmoc-L-Lys (Boc)-OH-13C6,15N2
    		Inhibitor
    Fmoc-L-Lys (Boc)-OH-13C6,15N2 is a 15N-labeled and 13C-labled Triclabendazole.
  • HY-B0413R
    Fenbendazole (Standard)
    		Inhibitor
    Fenbendazole (Standard) is the analytical standard of Fenbendazole. This product is intended for research and analytical applications. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
  • HY-12053AR
    Vinorelbine (ditartrate) (Standard)
    		Inhibitor
    Vinorelbine (ditartrate) (Standard) is the analytical standard of Vinorelbine (ditartrate). This product is intended for research and analytical applications. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
  • HY-137866
    Tubulin inhibitor 9
    		Inhibitor
    Tubulin inhibitor 9 (compound 7) is a tubulin (Microtubule/Tubulin)Inhibitors with anticancer activity (MDA-MB 231, IC50=0.9 nM).
  • HY-10340AR
    Tirbanibulin dihydrochloride (Standard)
    		Inhibitor
    Tirbanibulin (dihydrochloride) (Standard) is the analytical standard of Tirbanibulin (dihydrochloride). This product is intended for research and analytical applications. Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
  • HY-169882
    Tubulin inhibitor 49
    		Inhibitor
    Tubulin inhibitor 49 (Compound 18) is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell).
  • HY-110090
    UA62784
    		Inhibitor
    UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer.
  • HY-121989
    cis-Trismethoxy resveratrol
    		Inhibitor ≥98.0%
    Cis-trismethoxy resveratrol is a potent anti-mitotic reagent.Cis-trismethoxy resveratrol inhibits tubulin polymerization with an IC50 value of 4 μM.
  • HY-79255
    Fmoc-MMAF-OMe
    		Inhibitor
    Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs).
  • HY-122249
    MT-7
    		Inhibitor
    MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules.
  • HY-P10589
    Phomopsinamine A
    		Inhibitor
    Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC50 of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC50 =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC50 =0.32 μM).
  • HY-W011996
    2-Methylthiophenothiazine
    		Inhibitor ≥99.0%
    2-Methylthiophenothiazine (compound 17) is a precursor of tubulin inhibitor with potential anticancer activity and can inhibit tubulin aggregation.
  • HY-10340BR
    Tirbanibulin Mesylate (Standard)
    		Inhibitor
    Tirbanibulin (Mesylate) (Standard) is the analytical standard of Tirbanibulin (Mesylate). This product is intended for research and analytical applications. Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
  • HY-117841
    T900607
    		Inhibitor
    T900607 is an anti-tumor agent and targets microtubule polymerization.
  • HY-10222R
    Ixabepilone (Standard)
    		Inhibitor
    Ixabepilone (Standard) is the analytical standard of Ixabepilone. This product is intended for research and analytical applications. Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
  • HY-D2436
    PTX-PEG-Cy3
    		Inhibitor
    PTX-PEG-Cy3 (Paclitaxel-PEG-Cy3) is a Cy3 (HY-D0822) labeled PTX-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. PTX stabilizes tubulin polymerization. PTX can cause both mitotic arrest and apoptotic cell death. PTX also induces autophagy.
  • HY-W874392
    Tubulin polymerization-IN-74
    		Inhibitor
    Tubulin polymerization-IN-74 (compound 11) is a Tubulin polymerization inhibitor, with IC50 of 15 μM. Tubulin polymerization-IN-74 can be used in anticancer research.