2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113083R
    Acetaminophen glucuronide (Standard)
    Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen glucuronide (Standard)
  • HY-N11129
    3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside
    3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside is a chalcone glucoside that can be found in Acacia dealbata.
    3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside
  • HY-N13021
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn.
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid
  • HY-E70408
    12α-Hydroxysteroid dehydrogenase, bacillus sphaericus
    12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is a dehydrogenase expressed in Bacillus sphaericus. 12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is NAD-dependent and is active on both bound and unbound bile salts. This enzyme can be used to measure the concentration of 12α-hydroxy bile acids in serum.
    12α-Hydroxysteroid dehydrogenase, bacillus sphaericus
  • HY-N0473S11
    L-Tyrosine-15N,d7
    L-Tyrosine-15N,d7 is the deuterium and 15N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-<sup>15</sup>N,d<sub>7</sub>
  • HY-113486S1
    lathosterol-d7
    lathosterol-d7 is deuterium labeled Lathosterol (HY-113486). Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury[1].
    lathosterol-d<sub>7</sub>
  • HY-W017522S5
    Adipic acid-d44-1
    Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-d4<sub>4</sub>-1
  • HY-164093
    Isovaleryl-CoA
    Isovaleryl-CoA is an intermediate metabolite in the catabolic pathway of leucine. Isovaleryl-CoA is the starting unit for some secondary metabolites and iso-odd fatty acids in several bacteria.
    Isovaleryl-CoA
  • HY-119328
    Pestalotin
    Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore.
    Pestalotin
  • HY-118534A
    Cyclobutyrol sodium
    Cyclobutyrol sodium is a potent choleretic agent. Cyclobutyrol sodium also inhibits biliary lipid secretion. Cyclobutyrol sodium induces choleretic is unrelated to bile acids. Cyclobutyrol sodium and bile acids do not compete for the hepatobiliar transport mechanisms[1]
    Cyclobutyrol sodium
  • HY-113356
    m-Tyramine
    m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor[1, 2].
    m-Tyramine
  • HY-129953
    9α,11β-Prostaglandin F2α
    9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma.
    9α,11β-Prostaglandin F2α
  • HY-N1480S
    (-)-Fucose-13C
    (-)-Fucose-13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
    (-)-Fucose-<sup>13</sup>C
  • HY-41700S2
    D-Alanine-d
    D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].
    D-Alanine-d
  • HY-N0682S2
    Pyridoxine-d5 hydrochloride
    Pyridoxine-d5 (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride[1]. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway[2].
    Pyridoxine-d<sub>5</sub> hydrochloride
  • HY-E70316
    Chimax-O
    Chimax-O (Endo-chitosanase) is an endochitosanase belonging to the GH46 family that catalyzes chitosan substrate to produce chitobiose and D-glucosamine (GlcN). Chimax-O acts in a stochastic intra-action manner, producing chitosan derivatives with different degrees of polymerization (DP) ≤2.
    Chimax-O
  • HY-124221
    Radamide
    Radamide is an inhibitor of Grp94 with anti-migratory activity. Radamide is used to inhibit Grp94-related diseases such as glaucoma, cancer metastasis, and multiple myeloma. Radamide exhibits selective inhibitory activity by acting on the specific structure of Grp94. Radamide derivatives show better potency and selectivity in improved structure-activity relationship studies.
    Radamide
  • HY-B0234S3
    Estrone-13C2
    Estrone-13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
    Estrone-<sup>13</sup>C<sub>2</sub>
  • HY-17583S
    Griseofulvin-d3
    Griseofulvin-d3 is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal agent[1][2].
    Griseofulvin-d<sub>3</sub>
  • HY-N0111S
    Coenzyme Q10-d6
    Coenzyme Q10-d6 is deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity