2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
    Neuronal Signaling
  4. Histamine Receptor
  5. H1 Receptor Isoform

H1 Receptor

 

H1 Receptor Related Products (138):

Cat. No. Product Name Effect Purity
  • HY-119995
    Chloropyramine
    		Antagonist
    Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.
  • HY-A0069A
    Doxylamine
    		Antagonist
    Doxylamine, a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent.
  • HY-17042AS1
    Cetirizine-d8 dihydrochloride
    		Antagonist
    Cetirizine-d8 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
  • HY-B2178
    Emedastine difumarate
    		Agonist
    Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis.
  • HY-B0164S
    Mizolastine-13C,d3
    		Antagonist
    Mizolastine-13C,d3 is the 13C- and deuterium labeled Mizolastine.
  • HY-B0781S
    Promethazine-d4 hydrochloride
    		Antagonist ≥98.0%
    Promethazine-d4 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.
  • HY-B0548S1
    Hydroxyzine-d8
    		Antagonist ≥99.0%
    Hydroxyzine-d8 is deuterium labeled Hydroxyzine. Hydroxyzine is a histamine H1-receptor antagonist[1].
  • HY-117046A
    AVN-101 hydrochloride
    		Inhibitor 99.59%
    AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56  nM, and 1.17  nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis.
  • HY-B0286AS
    Chlorpheniramine-d4 maleate
    		Antagonist
    Chlorpheniramine-d4 (maleate) is deuterium labeled Chlorpheniramine (maleate).
  • HY-12752
    Alimemazine
    		Agonist
    Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties.
  • HY-17043S1
    Loratadine-d5
    		Agonist 99.96%
    Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
  • HY-B0640S
    Epinastine-13C,d3 hydrobromide
    		Antagonist
    Epinastine-13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].
  • HY-402545
    (-)-Brompheniramine
    		Antagonist 99.67%
    (-)-Brompheniramine is a H1 receptor antagonist with antiallergic activity.
  • HY-17428A
    Tripelennamine
    		Antagonist
    Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions.
  • HY-164430
    Arpromidine
    		Modulator
    Arpromidine (BU-E-50) is the agonist for histamine H2 receptor and the antagonist for histamine H1 receptor. Arpromidine exhibits positive inotropic effect with less risks in causing arrhythmias. Arpromidine can be used in research of congestive heart failure.
  • HY-17042B
    (S)-Cetirizine dihydrochloride
    		Antagonist
    (S)-Cetirizine (dihydrochloride) ((S)-P071) is an orally active antagonist of the histamine H1 receptor with a Ki value of 39.1 nM. (S)-Cetirizine (dihydrochloride) exerts anti-allergic activity by binding to the histamine H1 receptor and blocking the action of histamine. (S)-Cetirizine (dihydrochloride) is promising for research of allergic diseases such as allergic rhinitis.
  • HY-B0462A
    Azelastine
    		Antagonist
    Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
  • HY-114724
    HSR-609
    HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs.