G protein-coupled Bile Acid Receptor 1 Agonist

G protein-coupled Bile Acid Receptor 1 Agonists (41):

Cat. No.	Product Name	Effect	Purity

HY-128853S

Taurodeoxycholate-d₆ sodium salt	Agonist	99.4%
Taurodeoxycholate-d₆ sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate-d₆ sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate-d₆ sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d₆ (TDCA) exhibits anti-inflammatory and neuroprotective effects.

HY-101273

BAR502	Agonist	99.53%
BAR502 is a dual FXR and GPBAR1 agonist with IC₅₀ values of 2 μM and 0.4 μM, respectively.

HY-145234

GPBAR1-IN-3	Agonist
GPBAR1-IN-3 (Compound 14) is a selective GPBAR1 agonist (EC₅₀=0.17 μM) and a CysLT₁R antagonist.

HY-P2277A

PEN (rat) (TFA)	Agonist
PEN (rat) TFA, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

HY-107612

GPBAR-A	Agonist
GPBAR-A is a specific agonist of the bile acid receptor GPBAR1. GPBAR-A can be used for the research of diabetes mellitus.

HY-149807

TGR5 agonist 1	Agonist
TGR5 agonist 1 (compound 18) is a potent TGR5 agonist with an EC₅₀ value of 0.31 µM.

HY-142159

FXR/TGR5 agonist 1	Agonist
FXR/TGR5 agonist 1 has agonist action on FXR and TGR5, and can be used for the research of fatty liver disease.

HY-161817

TGR5 agonist 5	Agonist
TGR5 agonist 5 (compound K91) is a potent agonist of TGR5, with EC₅₀s of 19 μM and 30 μM in CRE-Luciferase assay anf cAMP accumulation assay, respectively.

HY-168329

TGR5 agonist 7	Agonist
TGR5 agonist 7 (Compound 22-Na) is a gut-restricted, orally active agonist for G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC₅₀ < 1 μM. TGR5 agonist 7 exhibits blood glucose lowering effect in mouse model, and can be used in diabete research.

HY-N0169A

Hyodeoxycholic acid sodium	Agonist
Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells.

HY-13771S1

Ursodeoxycholic acid-¹³C	Agonist
Ursodeoxycholic acid-¹³C is the ¹³C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

HY-146453

TGR5 Receptor Agonist 3	Agonist
TGR5 Receptor Agonist 3 (Compound 19) is a soft-agent G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist with reduced gallbladder-filling effects (favorable gallbladder safety), with EC50s of 16.4 and 209 nM for hTGR5 and mTGR5, respectively.

HY-N0169R

Hyodeoxycholic acid (Standard)	Agonist
Hyodeoxycholic acid (Standard) is the analytical standard of Hyodeoxycholic acid. This product is intended for research and analytical applications. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

HY-155307

TGR5 agonist 4	Agonist
TGR5 agonist 4 (compound 19), a cholic acid derivative, is a selective TGR5 agonist with an EC₅₀ of 4 μM.

HY-116453

RO5527239	Agonist
RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2.

HY-149808

TGR5 agonist 2	Agonist
TGR5 agonist 2 (compound 19) is a potent TGR5 agonist with an EC₅₀ value of 0.27 µM.

HY-13771R

Ursodeoxycholic acid (Standard)	Agonist
Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active.

HY-128853R

Taurodeoxycholate (sodium salt) (Standard)	Agonist
Taurodeoxycholate sodium salt (Standard) is a bile salt (Standard)-related anionic detergent. Taurodeoxycholate sodium salt (Standard) is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt (Standard) is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects.

HY-N0169S

Hyodeoxycholic acid-d₅	Agonist
Hyodeoxycholic acid-d₅ is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

HY-155306

TGR5 agonist 3	Agonist
TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC₅₀ of 5 μM.

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