2. Signaling Pathways
  3. Neuronal Signaling
  4. Dopamine Transporter

Dopamine Transporter

DAT; SLC6A3

Dopamine Transporter

Related Products

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Dopamine transporter (DAT) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (DA) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. DATs play a key role in terminating dopaminergic signalling and in maintaining a releasable pool of dopamine. DATs help to modulate the concentration of extraneuronal dopamine by actively shuttling released transmitter molecules back across the plasma membrane into dopaminergic neurons, where they can be sequestered for later reuse or enzymatic catabolism.

DAT is a principle target of various psychostimulant, nootropic, and antidepressant drugs, as well as certain drugs used recreationally, including the notoriously addictive stimulant cocaine. DAT ligands have traditionally been divided into two categories: cocaine-like inhibitors and amphetamine-like substrates. DAT is regulated by multiple signaling systems, such as PKC.

Dopamine Transporter Related Products (73):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101631
    Levophacetoperane hydrochloride
    		Inhibitor 98.00%
    Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.
    Levophacetoperane hydrochloride
  • HY-B1272R
    Desipramine (hydrochloride) (Standard)
    		Inhibitor
    Desipramine (hydrochloride) (Standard) is the analytical standard of Desipramine (hydrochloride). This product is intended for research and analytical applications. Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
    Desipramine (hydrochloride) (Standard)
  • HY-18610R
    Diclofensine (hydrochloride) (Standard)
    		Inhibitor
    Diclofensine (hydrochloride) (Standard) is the analytical standard of Diclofensine (hydrochloride). This product is intended for research and analytical applications.
    Diclofensine (hydrochloride) (Standard)
  • HY-18332
    Amitifadine
    		Inhibitor
    Amitifadine (DOV-21947) is an antidepressant drug candidate that functions as a triple reuptake inhibitor, targeting the reuptake of serotonin, norepinephrine, and dopamine, and has been shown to decrease binge drinking and alleviate negative emotions in animal models.
    Amitifadine
  • HY-B0557R
    Bisacodyl (Standard)
    		Inhibitor
    Bisacodyl (Standard) is the analytical standard of Bisacodyl. This product is intended for research and analytical applications. Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect.
    Bisacodyl (Standard)
  • HY-B1124R
    Fipexide (Standard)
    Fipexide (Standard) is the analytical standard of Fipexide. This product is intended for research and analytical applications. Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.
    Fipexide (Standard)
  • HY-163138
    DAT-IN-1
    		Inhibitor
    DAT-IN-1 (Coumpound 12b) is an atypical DAT inhibitor with a Ki of 8.37 nM. DAT-IN-1 can be used in the study of psychostimulant use disorder (PSUD).
    DAT-IN-1
  • HY-12242B
    GBR 12935 fumarate
    		Inhibitor
    GBR 12935 fumarate is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 fumarate stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 fumarate also prevents the d-Fenfluramine-induced head-twitch response in mice.
    GBR 12935 fumarate
  • HY-161913
    AC-4-248
    		Inhibitor
    AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively.
    AC-4-248
  • HY-169807
    O-2172
    		Inhibitor
    O-2172, a carbacyclic analog, is a DAT inhibitor, with IC50 values of 47 nM and 7000 nM for DAT and SERT, respectively.
    O-2172
  • HY-117512
    UWA-101 hydrochloride
    		Inhibitor
    UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease.
    UWA-101 hydrochloride
  • HY-101612
    SPD-473 citrate
    		Inhibitor 99.80%
    SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
    SPD-473 citrate
  • HY-19907
    Liafensine
    		Inhibitor
    Liafensine (BMS-820836) is a triple monoamine reuptake inhibitor (TRI), that inhibits dopamine transporter, serotonin transporter and norepinephrine transporter, with IC50s of 5.67, 1.08 and 7.99 nM, respectively. Liafensine exhibits antidepressant activity.
    Liafensine