Dopamine Receptor Agonist

Dopamine Receptor Agonists (109):

Cat. No.	Product Name	Effect	Purity

HY-124270

Sibenadet hydrochloride	Agonist
Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

HY-103424

A-412997 dihydrochloride	Agonist
A-412997 dihydrochloride is a selective dopamine D₄ receptor agonist. A-412997 dihydrochloride improves cognitive performance in rats and can be used in the research of psychiatric diseases.

HY-145454A

Preclamol	Agonist
Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses.

HY-12236B

(R)-SKF-81297 hydrobromide	Agonist
(R)-SKF-81297 hydrobromide is the R-enantiomer of SKF-81297 (HY-12236A). SKF-81297 is a selective agonist for dopamine D1 receptor.

HY-15296A

Cabergoline diphosphate	Agonist
Cabergoline diphosphate is an ergot derived-dopamine D₂-like receptor agonist that has high affinity for D₂, D₃, and 5-HT_2B receptors (K_i=0.7, 1.5, and 1.2, respectively).

HY-163830

Pegasus	Agonist
Pegasus (DAD9) is a potent dopamine receptor agonist. Pegasus shows antioxidant and anti-inflammatory properties. Pegasus inhibits α-Syn amyloid aggregation. Pegasus has the potential for the research of Parkinson’s disease.

HY-119943B

(R)-PF-06256142	Agonist	99.60%
(R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists.

HY-13720AR

Pergolide (mesylate) (Standard)	Agonist
Pergolide (mesylate) (Standard) is the analytical standard of Pergolide (mesylate). This product is intended for research and analytical applications. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.

HY-120405

RS-12254	Agonist
RS-12254 is a compound with hypotensive, diuretic and sympathostatic effects, and has the activity of regulating blood pressure, water and salt metabolism and sympathetic nerve activity. RS-12254 can lower blood pressure, reduce plasma norepinephrine levels, has diuretic and natriuretic effects, and has sympathostatic properties.

HY-120740

4-Amino-PPHT	Agonist
4-Amino-PPHT (Compound 9a) is a PPHT derivative that selectively binds to dopamine D-2 receptors with a K_i value of 6.8 nM.

HY-151515

Dopamine D2 receptor agonist-2	Agonist
Dopamine D2 receptor agonist-2 (compound 36) is a potent dopamine D₂ receptor biased agonism ligand with an K_i value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis.

HY-14546R

Aripiprazole (Standard)	Agonist
Aripiprazole (Standard) is the analytical standard of Aripiprazole. This product is intended for research and analytical applications. Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

HY-117436

R(+)-6-Bromo-APB hydrobromide	Agonist
R(+)-6-Bromo-APB hydrobromide is a dopamine (DA) agonist. R(+)-6-Bromo-APB hydrobromide increased the expression of µ opioid receptor (MOR) mRNA in the nucleus accumbens.

HY-106100

Roxindole	Agonist
Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT_1A agonist and 5-HT uptake inhibitor. Antipsychotic and antidepressant activities.

HY-P1444

Acein	Agonist
Acein is a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Acein can promote the release of dopamine. Acein targets angiotensin converting enzyme (ACE I). Angiotensin converting enzyme (ACE I) can be used in nervous system related research.

HY-12705AR

Bromocriptine (mesylate) (Standard)	Agonist
Bromocriptine (mesylate) (Standard) is the analytical standard of Bromocriptine (mesylate). This product is intended for research and analytical applications. Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

HY-13720S

Pergolide-d₇ hydrochloride	Agonist
Pergolide-d₇ hydrochloride is deuterated labeled Pergolide (HY-13720). Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research.

HY-P10435

KEMPFPKYPVEP	Agonist
KEMPFPKYPVEP is a 12-amino acids neuropeptide, which upregulates levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex, exhibits spatial and object recognition memory promoting ability in Scopolamine (HY-N0296)-induced amnesia mouse model.

HY-12705

Bromocriptine	Agonist
Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pK_i of 8.05±0.2.

HY-N0049R

Nuciferine (Standard)	Agonist
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

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