Cytochrome P450 Inhibitor

Cytochrome P450 Inhibitors (300):

Cat. No.	Product Name	Effect	Purity

HY-B0105B

(-)-Ketoconazole	Inhibitor	99.39%
(-)-Ketoconazole ((-)-R 41400) is one of the enantiomers of ketoconazole (HY-B0105). Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole). Ketoconazole is an antifungal agent and a cytochrome P450 inhibitor.

HY-109123

Soticlestat	Inhibitor	99.93%
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research.

HY-N2420

Flavokawain A	Inhibitor	99.93%
Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer.

HY-N0762

Isobavachin	Inhibitor	99.86%
Isobavachin, an antioxidant isaolated from Psoralea corylifolia with a prenyl group at position 8 of ring A, promotes neuronal differentiation and the potential role of its protein prenylation.

HY-147277

Lorundrostat	Inhibitor	99.37%
Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure.

HY-N0094

Ipriflavone	Inhibitor	99.89%
Ipriflavone is a synthetic isoflavone derivative used to suppress bone resorption.

HY-137258

(±)-N-3-Benzylnirvanol	Inhibitor	99.88%
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with K_i values of 0.25 and 5.3 μM for CYP2C19, respectively.

HY-160972

MM0299	Inhibitor	98.51%
MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC₅₀ of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC₅₀ of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol.

HY-B1234

Octinoxate	Inhibitor	99.89%
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.

HY-B0873

Uniconazole	Inhibitor	99.68%
Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC₅₀ of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a K_i of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent.

HY-111430

1-Ethynylnaphthalene	Inhibitor	99.27%
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. 1-Ethynylnaphthalene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14273S

Isavuconazole-d₄	Inhibitor	99.88%
Isavuconazole-d₄ is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi[1].

HY-135549

Fluxapyroxad	Inhibitor	99.96%
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.

HY-B0615A

Moricizine Hydrochloride	Inhibitor	≥98.0%
Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period.

HY-121188

DDMS	Inhibitor	99.19%
DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP).

HY-A0296

Chlormethiazole hydrochloride	Inhibitor	99.94%
Clomethiazole hydrochloride is a anticonvulsant. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA).

HY-W327449

Feruloylputrescine	Inhibitor	99.34%
Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research.

HY-131452

1-Ethynylpyrene	Inhibitor
1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1 with IC₅₀s of 0.18, 0.32, and 0.04 μM, respectively. 1-Ethynylpyrene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103061

Dehydro-ZINC39395747	Inhibitor	99.20%
Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC₅₀ of 9.14 μM and a K_d of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells.

HY-B0105A

(+)-Ketoconazole	Inhibitor	99.79%
(+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor.

Name
Email *

	Sorry, but the email address you supplied was invalid.