Calcium Channel Inhibitor

Calcium Channel Inhibitors (337):

Cat. No.	Product Name	Effect	Purity

HY-14744D

Levamlodipine besylate Hemipentahydrate	Inhibitor
Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine (HY-14744). Levamlodipine besylate hemipentahydrate is an orally active calcium channel blocker with antioxidant and vasodilatory properties. Levamlodipine besylate hemipentahydrate can reduce serum malondialdehyde (MDA) levels, increase superoxide dismutase (SOD) activity, and improve oxidative stress. Levamlodipine besylate hemipentahydrate can be used for research on vascular dementia, hypertension, and cerebrovascular diseases.

HY-B0612C

(R)-Lercanidipine	Inhibitor
(R)-Lercanidipine is the R-enantiomer of Lercanidipine. (R)-lercanidipine is a calcium channel blocker.

HY-17404S1

Cilnidipine-d₄	Inhibitor
Cilnidipine-d₄ (FRC-8653-d₄) is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca²⁺-channel blocker on L and N-type Ca²⁺ channel. Antihypertensive effects.

HY-A0016R

Dronedarone (Standard)	Inhibitor
Dronedarone (Standard) is the analytical standard of Dronedarone. This product is intended for research and analytical applications. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.

HY-123468A

HA-1004 di(hydrochloride)	Inhibitor
HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.

HY-124229

PD 122860	Inhibitor
PD 122860 is a calcium channel blocker. PD 122860 also can stimulate sodium channel. PD 122860 can be used for the research of cardiovascular and cerebrovascular diseases.

HY-B0632R

Diltiazem (Standard)	Inhibitor
Diltiazem (Standard) is the analytical standard of Diltiazem. This product is intended for research and analytical applications. Diltiazem is an orally active L-type Ca²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.

HY-17402R

Nisoldipine (Standard)	Inhibitor
Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-W032013S2

1-Octanol-d₂-1	Inhibitor
1-Octanol-d₂-1 is deuterated labeled Cinnamyl acetate (HY-N7125). Cinnamyl acetate has a wide application in the flavor and fragrance industry. Cinnamyl acetate is a new broad spectrum antibacterial agent.

HY-B0419S

Manidipine-d₄	Inhibitor
Manidipine-d₄ is the deuterium labeled Manidipine (HY-B0419). Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy.

HY-B0233R

Isradipine (Standard)	Inhibitor
Isradipine (Standard) is the analytical standard of Isradipine. This product is intended for research and analytical applications. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.

HY-W699430

Norverapamil-d₆ hydrochloride	Inhibitor
Norverapamil-d₆ ((±)-Norverapamil-d₆) hydrochloride is deuterium labeled Norverapamil (hydrochloride). Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

HY-B0280R

Ranolazine (Standard)	Inhibitor
Ranolazine (Standard) is the analytical standard of Ranolazine. This product is intended for research and analytical applications. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.

HY-169333

1,4-Dihydropyridine	Inhibitor
1,4-Dihydropyridine is an inhibitor for calcium channel, that blocks the L-type calcium channels, reduces the influx of calcium ions into cardiac and vascular smooth muscle cells, and thus reduces the contractility and heart rate of the heart, dilates blood vessels, and lowers blood pressure.

HY-117055

Ro 18-3981	Inhibitor
Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca²⁺ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (V_h=-20 mV: IC₅₀=2.3 nM; V_h=-50 mV: IC₅₀=100 nM).

HY-17402S2

Nisoldipine-d₇	Inhibitor
Nisoldipine-d₇ (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-A0016S3

Dronedarone-d₆	Inhibitor
Dronedarone-d₆ (SR 33589-d₆) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.

HY-P2061

Leualacin	Inhibitor
Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.

HY-101621

Teludipine hydrochloride	Inhibitor
Teludipine is a lipophilic calcium channel blocker.

HY-101621S

Teludipine-d₆	Inhibitor
Teludipine-d₆ is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker[1][2].

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