Calcium Channel Activator

Calcium Channel Activators (40):

Cat. No.	Product Name	Effect	Purity

HY-150135B

D-myo-Inositol 1,4,5-trisphosphate tripotassium	Activator	98.00%
D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca²⁺ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2).

HY-P3037

Imperatoxin A	Activator
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca²⁺-release channels/ryanodine receptors (RyRs) enhances the influx of Ca²⁺ from the sarcoplasmatic reticulum into the cell.

HY-100718

SCH00013	Activator
SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.

HY-111014

VK-II-36	Activator	99.63%
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca²⁺release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations.

HY-B0282R

Acetylcholine chloride (Standard)	Activator
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.

HY-P3037A

Imperatoxin A TFA	Activator	98.65%
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca²⁺-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca²⁺ from the sarcoplasmatic reticulum into the cell.

HY-12323G

ISX-9 (GMP)	Activator
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

HY-P1117A

MMK1 TFA	Activator
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.

HY-P1987

Mast cell degranulating peptide (28-49)	Activator
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices.

HY-135110

Rp-8-Br-cGMPS sodium	Activator
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca²⁺ reduction by activating Ca²⁺-ATPase and subsequently removing Ca²⁺ from the cell.

HY-137672A

2',3'-Cyclic NADP disodium	Activator
2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.

HY-138119A

γ-Glutamylserine TFA	Activator
γ-Glutamylserine TFA (γ-Glu-Ser TFA) is a calcium receptor activator. γ-Glutamylserine TFA can be used for Parkinson's disease research, as well as diabetes or obesity study.

HY-138806

PAQ	Activator
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.

HY-P5319

MCaE12A	Activator
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell.

HY-W654013

Minocycline-d₇	Activator
Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

HY-118136

CGP 28392	Activator
CGP 28392 is an activator for calcium channel, and reactivates the oxygen evolution in calcium-deficient photosystem II (PS II) particles.

HY-130358

PDDHV	Activator
PDDHV is a calcium absorption inducer and may achieve 45Ca²⁺ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca²⁺ uptake (EC₅₀: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC₅₀: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats.

HY-135110A

Rp-8-Br-cGMPS	Activator
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca²⁺ reduction by activating Ca²⁺-ATPase and subsequently removing Ca²⁺ from the cell.

HY-155394

RyRs activator 5	Activator
RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda.

HY-W010451R

1,2,4-Trihydroxybenzene (Standard)	Activator
1,2,4-Trihydroxybenzene (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene. This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes.

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