2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16126R
    Carboxyamidotriazole (Standard)
    		Inhibitor
    Carboxyamidotriazole (Standard) is the analytical standard of Carboxyamidotriazole. This product is intended for research and analytical applications. Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.
    Carboxyamidotriazole (Standard)
  • HY-W037193
    Calcium Channel antagonist 5
    		Antagonist
    Calcium Channel antagonist 5 (compound 32) is a calcium channel antagonist with a pIC50 of 5.50.
    Calcium Channel antagonist 5
  • HY-149779
    RyR2 stabilizer-1
    		Modulator
    RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias.
    RyR2 stabilizer-1
  • HY-B0233S
    Isradipine-d3
    		Inhibitor
    Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].
    Isradipine-d<sub>3</sub>
  • HY-A0016S
    Dronedarone-d6 hydrochloride
    		Inhibitor
    Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
    Dronedarone-d<sub>6</sub> hydrochloride
  • HY-N1593
    15-Methoxypinusolidic acid
    		Inhibitor
    15-Methoxypinusolidic acid (compound 1) is a labdane diterpene compound isolated from the leaves of Calocedrus microlepic.
    15-Methoxypinusolidic acid
  • HY-12502B
    Efonidipine hydrochloride
    		Inhibitor
    Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
    Efonidipine hydrochloride
  • HY-U00250
    β-Amino Acid Imagabalin Hydrochloride
    β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.
    β-Amino Acid Imagabalin Hydrochloride
  • HY-P0268
    Myomodulin
    		Modulator
    Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
    Myomodulin
  • HY-U00354
    CP-060
    		Antagonist
    CP-​060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.
    CP-060
  • HY-U00218
    McN5691
    		Inhibitor
    McN5691 is a voltage-sensitive calcium channel blocker.
    McN5691
  • HY-U00135
    Calcium channel-modulator-1
    		Modulator 98.77%
    Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.
    Calcium channel-modulator-1
  • HY-U00388
    α2δ ligand 1
    		Chemical
    α2δ ligand 1 is a ligand to the α2δ-1 subunit of voltage-sensitive calcium channel, extracted from patent US20040186177.
    α2δ ligand 1
  • HY-U00236
    PD0176078
    		Inhibitor 99.80%
    PD0176078 is a newly found N-type Calcium channel blocker.
    PD0176078
  • HY-U00151
    Dopropidil
    		Antagonist
    Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
    Dopropidil
  • HY-U00086
    Darodipine
    		Antagonist
    Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
    Darodipine
  • HY-U00284
    AE0047 Hydrochloride
    		Antagonist
    AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.
    AE0047 Hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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