AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. AChE plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins.

AChE Related Products (255):

By Type:	Pan (60) Selective (35)
By Effects:	Inhibitors (242) Agonist (1) Antagonist (1) Activators (4) Modulator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-N2320

Physostigmine hemisulfate	Inhibitor	≥99.0%
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning.

HY-B2244

Tacrine hydrochloride (hydrate)	Inhibitor	99.98%
Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC₅₀s of 31 nM and 25.6 nM, respectively.

HY-B0841

Acephate	Inhibitor	≥98.0%
Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (AChE.html" class="link-product" target="_blank">Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture.

HY-N0241

Rhodionin	Inhibitor	98.78%
Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC₅₀ of 0.761 μM and a Ki of 0.769 μM. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC₅₀ ranged from 57.50 to 2.43 μg/mL. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC₅₀ of 19.49 μM.

HY-N0702

Tenuifolin	Inhibitor	99.24%
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

HY-17388

(±)-Huperzine A	Inhibitor	98.73%
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

HY-124957

β-NETA	Inhibitor	≥98.0%
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC₅₀=76 μM) and cholinesterase (ChE; IC₅₀=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC₅₀=1 mM).

HY-118165

Phenthoate	Inhibitor	98.71%
Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor.

HY-100620

RPR121056	Inhibitor	99.59%
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.

HY-103374

Phenserine	Inhibitor	99.55%
Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease.

HY-N0749A

Jatrorrhizine hydroxide	Inhibitor	98.07%
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.

HY-B1738A

Pralidoxime iodide	Activator	≥98.0%
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA	Chemical	99.45%
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).

HY-100919

Ambenonium chloride	Inhibitor
Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC₅₀ value of 0.7 nM (hAChE).

HY-N2211

Picfeltarraenin IB	Inhibitor	98.53%
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.

HY-122203

PCS1055 dihydrochloride	Inhibitor	98.88%
PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC₅₀ s of 22 nM and 120 nM for electric eel and human AChE, respectively.

HY-W014700

Glycyl-L-glutamic acid	Modulator
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration.

HY-N7993

Manghaslin	Inhibitor	98.56%
Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC₅₀ of 94.92 μM.

HY-N1474

Picfeltarraenin IA	Inhibitor	99.83%
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation.

HY-B1093

Fenchlorphos	Inhibitor	99.87%
Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.

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