AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. AChE plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins.

AChE Related Products (255):

By Type:	Pan (60) Selective (35)
By Effects:	Inhibitors (242) Agonist (1) Antagonist (1) Activators (4) Modulator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-157296

AChE-IN-47	Inhibitor
AChE-IN-47 (compound g17) is a AChE inhibitor with the IC₅₀ of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species.

HY-115973

AChE-IN-11	Inhibitor
AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 (IC₅₀=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease.

HY-144775

AChE-IN-10	Inhibitor
AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC₅₀ = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE.

HY-127165

Velnacrine	Inhibitor
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC₅₀ of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD₅₀ of 65 mg/kg.

HY-169961

BChE-IN-38	Inhibitor
BChE-IN-38 (compound 13) is a potent BChE inhibitor with K_i values of 62.05, 28.78, 14.09, 1.15 nM for hCAI, hCAII, AChE, BChE, respectively. BChE-IN-38 shows cytotoxic activity.

HY-161243

AChE-IN-56	Inhibitor
AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy.

HY-149288

hAChE/hBACE-1-IN-2	Inhibitor
hAChE/hBACE-1-IN-2 is a potent, orally active, blood-brain barrier transboundary triple inhibitor of hAChE, hBChE, and HACE-1 with IC₅₀s of 0.113 μM, 1.48 μM and 0.38 μM, respectively. hAChE/hBACE-1-IN-2 has antioxidant activity. hAChE/hBACE-1-IN-2 also inhibits Aβ1_1-42 aggregation. hAChE/hBACE-1-IN-2 can be used to study Alzheimer's disease.

HY-162338

BChE-IN-29	Inhibitor
BChE-IN-29 (Compound 27a) is a BChE inhibitor (IC₅₀: 0.078 μM and 0.74 μM for BChE and AChE respectively). BChE-IN-29 has anti-inflammatory activity and can be used for research of AD.

HY-134137

Donepezil N-oxide	Inhibitor
Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor.

HY-18039

WAY-361789	Agonist
WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC₅₀ of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia.

HY-N2971

Buxbodine B	Inhibitor
Buxbodine B is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 50 μM. Buxbodine B can be used in research of Alzheimer's disease.

HY-169173

AL284	Inhibitor
AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes.

HY-161029

T14-A24	Inhibitor
T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (K_i=22 nM, IC₅₀=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile.

HY-W049312

7-Methoxytacrine	Inhibitor
7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC₅₀ value of 10 μM, and can be used for the research of Alzheimer's disease (AD).

HY-115650

TAE-1	Inhibitor
TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease.

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