2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15267B
    (24S)-MC 976 112849-14-6
    (24S)-MC 976 is a Vitamin D3 derivative.
    (24S)-MC 976
  • HY-P0245
    Speract 76901-59-2
    Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
    Speract
  • HY-P0321
    Asp-Asp-Asp-Asp-Asp 124219-00-7
    Asp-Asp-Asp-Asp-Asp is a peptide consists of 5 Asp.
    Asp-Asp-Asp-Asp-Asp
  • HY-U00176
    Org30958 99957-90-1
    Org30958 is a potent aromatase inhibitor in vivo.
    Org30958
  • HY-U00198
    Topterone 60607-35-4
    Topterone is a topical antiandrogen.
    Topterone
  • HY-U00220
    KAT681 373641-87-3
    KAT681 is a liver-selective thyromimetic.
    KAT681
  • HY-U00290
    R-(+)-Mono-desmethylsibutramine 229639-54-7
    R-(+)-Mono-desmethylsibutramine is the R enantiomer of Mono-desmethylsibutramine.
    R-(+)-Mono-desmethylsibutramine
  • HY-U00303
    Trecadrine 90845-56-0
    Trecadrine is a β3-adrenergic agonist.
    Trecadrine
  • HY-U00358
    Compound 2 872313-42-3
    Compound 2 is an active compound used for the research of metabolic bone diseases.
    Compound 2
  • HY-U00376
    5α-reductase-IN-1 119348-12-8
    5α-reductase-IN-1 is an inhibitor of 5α-reductase, used for the research of patterned alopecia in combination with minoxidil.
    5α-reductase-IN-1
  • HY-101648
    ACAT-IN-1 cis isomer 145961-79-1
    ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM.
    ACAT-IN-1 cis isomer
  • HY-U00020
    AU-224 287399-47-7
    AU-224 is a benzamide derivative used as a promising gastrointestinal prokinetic agent without significant side effects.
    AU-224
  • HY-U00059
    Pyrrole-derivative1 474006-30-9
    Pyrrole-derivative1 is extracted from patent WO/2002/085851A1, example 2, developed for the treatment of diabetic disease.
    Pyrrole-derivative1
  • HY-U00068
    PPARα-MO-1 810677-36-2
    PPARα-MO-1 is a potent PPARα modulator extracted from patent WO/2004/110982A1, formula I.
    PPARα-MO-1
  • HY-U00171
    SQ28603 100845-83-8
    SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
    SQ28603
  • HY-U00193
    Ro18-5362 101387-97-7
    Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.
    Ro18-5362
  • HY-U00200
    Dicirenone 41020-79-5
    Dicirenone (SC26304) inhibits the effects of Aldosterone on urinary K+:Na+ ratios and the binding of [3H]Aldosterone to renal cytoplasmic and nuclear receptors.
    Dicirenone
  • HY-U00216
    NNC45-0781 207277-66-5
    NNC45-0781 is a tissue-selective estrogen partial-agonist.
    NNC45-0781
  • HY-U00244
    Benzquinamide 63-12-7
    Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively.
    Benzquinamide
  • HY-U00245
    L162441 154512-46-6
    L162441 is an Angiotensin type 1 receptor antagonist.
    L162441
Cat. No. Product Name / Synonyms Application Reactivity